<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932014000100011</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2014.01(01)69-070</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Monitoreo hemodinámico utilizando variabilidad del volumen sistólico como parámetro para guiar el manejo de líquidos en pacientes sépticos]]></article-title>
<article-title xml:lang="en"><![CDATA[Hemodynamic monitoring using the variability of the systolic volume as a parameter to guide the fluid management in septic patients]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aquino Millán]]></surname>
<given-names><![CDATA[Víctor]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bianco Cáceres]]></surname>
<given-names><![CDATA[Hugo]]></given-names>
</name>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fretes Ruiz]]></surname>
<given-names><![CDATA[Ariel]]></given-names>
</name>
<xref ref-type="aff" rid="A03"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Figueredo]]></surname>
<given-names><![CDATA[Belinda]]></given-names>
</name>
<xref ref-type="aff" rid="A04"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira Marecos]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="A05"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Hospital de Clínicas]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="A02">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Hospital de Clínicas]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="A03">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Hospital de Clínicas]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="A04">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Hospital de Clínicas]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="A05">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Hospital de Clínicas]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2014</year>
</pub-date>
<volume>1</volume>
<numero>1</numero>
<fpage>69</fpage>
<lpage>70</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932014000100011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932014000100011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932014000100011&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Se presenta una serie de casos donde se compara la variabilidad del volumen sistólico con las variables estáticas habituales en la reanimación con fluidos de pacientes sépticos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[We report a case series where the variability of the systolic volume is compared to the usual static variables of the fluid resuscitation of septic patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[variabilidad del volumen sistólico]]></kwd>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="es"><![CDATA[hidratación parenteral]]></kwd>
<kwd lng="en"><![CDATA[systolic volume variability]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[parenteral hydration]]></kwd>
</kwd-group>
</article-meta>
</front><body><![CDATA[ <p align="right"><font size="2" face="Verdana, Geneva, sans-serif"><b>REPORTE DE CASOS</b></font></p>      <p>&nbsp;</p>     <p><font size="4" face="Verdana, Geneva, sans-serif"><b>Monitoreo hemodin&aacute;mico utilizando  variabilidad del volumen sist&oacute;lico como par&aacute;metro para guiar el manejo de l&iacute;quidos  en pacientes s&eacute;pticos</b></font></p>     <p><font size="3" face="Verdana, Geneva, sans-serif"><b>Hemodynamic  monitoring using the variability of the systolic volume as a parameter to guide  the fluid management in septic patients</b></font></p>      <p><font size="2" face="Verdana, Geneva, sans-serif"><b>Autores</b>: V&iacute;ctor Aquino  Mill&aacute;n<sup><a href="#corresp1">1</a></sup><a name="autor1" id="autor1"></a>, Hugo Bianco C&aacute;ceres<sup><a href="#corresp2">2</a><a name="autor2" id="autor2"></a></sup>, Ariel Fretes Ruiz<sup><a href="#corresp3">3</a><a name="autor3" id="autor3"></a></sup>, Belinda Figueredo<sup><a href="#corresp4">4</a><a name="autor4" id="autor4"></a></sup>,  Fernando Ferreira Marecos<sup><a href="#corresp5">5</a><a name="autor5" id="autor5"></a></sup></font></p> <hr size "1" noshade>     <p>&nbsp;</p>       <p><font size="3" face="Verdana, Geneva, sans-serif"><b> Resumen</b></font></p>     <p><font size="2" face="Verdana, Geneva, sans-serif">Se  presenta una serie de casos donde se compara la variabilidad del volumen  sist&oacute;lico con las variables est&aacute;ticas habituales en la reanimaci&oacute;n con fluidos  de pacientes s&eacute;pticos.</font></p>     <p><font size="2" face="Verdana, Geneva, sans-serif"><b> Palabras claves</b>: variabilidad  del volumen sist&oacute;lico, sepsis, hidrataci&oacute;n parenteral</font></p> <hr size "1" noshade>     <p>&nbsp;</p>      ]]></body>
<body><![CDATA[<p><font size="3" face="Verdana, Geneva, sans-serif"><b> Abstract</b></font></p>     <p><font size="2" face="Verdana, Geneva, sans-serif">We report a case  series where the variability of the systolic volume is compared to the usual  static variables of the fluid resuscitation of septic patients.</font></p>     <p><font size="2" face="Verdana, Geneva, sans-serif"><b> Keywords</b>:  systolic volume variability, sepsis, parenteral hydration</font></p> <hr size "1" noshade>     <p>&nbsp;</p>      <p><font size="3" face="Verdana, Geneva, sans-serif"><b> Introducci&oacute;n</b></font></p>     <p><font size="2" face="Verdana, Geneva, sans-serif">La clave en el  tratamiento inicial de la sepsis es el  manejo de los l&iacute;quidos corporales y conocer la cantidad exacta de fluidos a  administrar es un desaf&iacute;o en cada paciente.<sup>1,2,3</sup> La precisi&oacute;n de las variables est&aacute;ticas como  objetivo en la reanimaci&oacute;n, tales como la frecuencia cardiaca (FC), tensi&oacute;n  arterial media (TAM) y presi&oacute;n venosa central (PVC), pareciera ser limitada en  comparaci&oacute;n a las din&aacute;micas como la variabilidad del volumen sist&oacute;lico (VVS).<sup>4,5</sup>  El uso de dichos elementos nos orientar&iacute;a con certeza hacia el manejo &oacute;ptimo de  la volemia.<sup>6,7</sup></font></p>      <p>&nbsp;</p>     <p><font size="3" face="Verdana, Geneva, sans-serif"><b>Objetivo</b></font></p>     <p><font size="2" face="Verdana, Geneva, sans-serif">Determinar el  nivel de volemia en pacientes con sepsis severa luego de la resucitaci&oacute;n  inicial utilizando la VVS para dicho efecto.</font></p>        <p>&nbsp;</p>     ]]></body>
<body><![CDATA[<p><font size="3" face="Verdana, Geneva, sans-serif"><b>Materiales y m&eacute;todos</b></font></p>     <p><font size="2" face="Verdana, Geneva, sans-serif">Dise&ntilde;o  observacional, retrospectivo, de corte transverso. Se incluyeron pacientes en  el periodo comprendido entre marzo y junio del 2013, sin patolog&iacute;a de base, que  ingresaron a la Unidad de terapia intensiva de adultos del Hospital de Cl&iacute;nicas,  FCM-U.N.A. con sepsis severa y requerimiento de asistencia respiratoria mec&aacute;nica. Luego de haberse realizado la  resucitaci&oacute;n inicial siguiendo las gu&iacute;as de la campa&ntilde;a sobreviviendo la sepsis4,  se midi&oacute; la VVS con el <i> Clinic Platform EV  1000</i> mediante el sensor <i> Floctrac</i> como par&aacute;metro para valorar el volumen del l&iacute;quido intravascular teniendo como  punto de corte para d&eacute;ficit de volumen una VVS&gt;13%.<sup>3,6</sup></font></p>      <p>&nbsp;</p>     <p><font size="3" face="Verdana, Geneva, sans-serif"><b>Resultados</b></font></p>     <p><font size="2" face="Verdana, Geneva, sans-serif">Se incluyeron 3  pacientes de sexo masculino que ingresaron a terapia intensiva, con edad media  29,3 a&ntilde;os (rango 16-43), con diagn&oacute;stico de sepsis severa a punto de partida  abdominal. Luego de la resucitaci&oacute;n inicial presentaron las siguientes  variables promedio: FC 94,3 latidos x minuto (rango 73-110), TAM 82,3 mm Hg (rango  70-95), PVC 15,3cm H<sub>2</sub>O (rango 13-18). Sin embargo, la VVS fue 20% (rango  17-26). </font></p>      <p>&nbsp;</p>     <p><font size="3" face="Verdana, Geneva, sans-serif"><b>Discusi&oacute;n</b></font></p>     <p><font size="2" face="Verdana, Geneva, sans-serif">Se observ&oacute; en  todos los casos que la volemia no era &oacute;ptima luego de la resucitaci&oacute;n habitual.  Mientras que los objetivos de PVC, FC, TAM estaban dentro de los par&aacute;metros &oacute;ptimos, la VVS suger&iacute;a hipovolemia.</font></p>     <p><font size="2" face="Verdana, Geneva, sans-serif">En relaci&oacute;n a la  evoluci&oacute;n posterior de estos pacientes, uno fue de alta a los 60 d&iacute;as de  internaci&oacute;n, el segundo fallece a los 30 d&iacute;as por choque s&eacute;ptico a punto de  partida pulmonar y el tercero tambi&eacute;n fallece a los 20 d&iacute;as por choque s&eacute;ptico  a punta de partida pulmonar y abdominal. </font></p>     <p><font size="2" face="Verdana, Geneva, sans-serif">Se concluye que  es de gran utilidad contar con par&aacute;metros din&aacute;micos para monitorizar la  resucitaci&oacute;n en los pacientes s&eacute;pticos pero se requieren m&aacute;s estudios para  corroborar estos hallazgos.</font></p>      ]]></body>
<body><![CDATA[<p>&nbsp;</p>     <p><font size="3" face="Verdana, Geneva, sans-serif"><b>Referencias bibliogr&aacute;ficas</b></font></p>     <!-- ref --><p><font size="2" face="Verdana, Geneva, sans-serif">1.  Cannesson M, Musard H, Desebbe O, Boucau C, Simon R, H&eacute;naine R, Lehot JJ. The  ability of stroke volume variations obtained with Vigileo/FloTrac system to  monitor fluid responsiveness in mechanically ventilated patients. Anesth  Analg. 2009 Feb; 108(2): 513-7.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=224959&pid=S2312-3893201400010001100001&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font></p>     <!-- ref --><p><font size="2" face="Verdana, Geneva, sans-serif">2. Benes  J, Chytra I, Altmann P, Hluchy M, Kasal E, Svitak R, Pradl R, Stepan M.  Intraoperative fluid optimization using stroke volume variation in high risk  surgical patients: results of prospective randomized study. Crit Care. 2010;  14(3): R118.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=224961&pid=S2312-3893201400010001100002&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --> </font></p>     <!-- ref --><p><font size="2" face="Verdana, Geneva, sans-serif">3. Michard  F. Changes in arterial pressure during mechanical ventilation. Anesthesiology  2005 Aug; 103(2): 419-428.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=224963&pid=S2312-3893201400010001100003&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font></p>     <!-- ref --><p><font size="2" face="Verdana, Geneva, sans-serif">4. Durairaj  L, Schmidt GA. Fluid therapy in resuscitated sepsis: less is more. Chest. 2008  Jan; 133(1): 252-63.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=224965&pid=S2312-3893201400010001100004&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font></p>     ]]></body>
<body><![CDATA[<!-- ref --><p><font size="2" face="Verdana, Geneva, sans-serif">5. Rivers  E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B et al. Early goal-directed therapy in  the treatment of severe sepsis and septic shock. N Engl J  Med. 2001 Nov 8; 345(19): 1368-77.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=224967&pid=S2312-3893201400010001100005&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font></p>     <!-- ref --><p><font size="2" face="Verdana, Geneva, sans-serif">6. Monnet  X, Gu&eacute;rin L, Jozwiak M, Bataille A, Julien F, Richard C, Teboul JL. Pleth  variability index is a weak predictor of fluid responsiveness in patients  receiving norepinephrine. Br J Anaesth. 2013 Feb; 110(2): 207-13.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=224969&pid=S2312-3893201400010001100006&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --> </font></p>     <!-- ref --><p><font size="2" face="Verdana, Geneva, sans-serif">7. Monnet  X, Anguel N, Jozwiak M, Richard C, Teboul JL. Third-generation FloTrac/Vigileo  does not reliably track changes in cardiac output induced by norepinephrine in  critically ill  patients. Br J Anaesth. 2012 Apr; 108(4): 615-22.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=224971&pid=S2312-3893201400010001100007&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font></p>     <p>&nbsp;</p>         <p><font size="2" face="Verdana, Geneva, sans-serif"><b>Art&iacute;culo  recibido:</b> 11 febrero 2014&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>Art&iacute;culo aceptado:</b> 23 febrero 2014</font></p>     <p><font size="2" face="Verdana, Geneva, sans-serif"><b>Autor correspondiente:</b><br /> Dr.  V&iacute;ctor Aquino Mill&aacute;n. Especialista en Medicina Interna<br /> Direcci&oacute;n:  Guayaibi entre Ettiene y Juana de Lara. Zona Norte. Fernando de la Mora,  Paraguay <br /> Tel&eacute;fono:  (595)981179008<br /> Correo  electr&oacute;nico: <a href="mailto:victoraquino81@gmail.com">victoraquino81@gmail.com</a></font></p>     <p><font size="2" face="Verdana, Geneva, sans-serif"><sup><a name="corresp1" id="corresp1"></a><a href="#autor1">1</a></sup> M&eacute;dico  de guardia. Unidad de Terapia  Intensiva Adultos, Hospital de Cl&iacute;nicas. FCM-UNA    ]]></body>
<body><![CDATA[<br>   <a name="corresp2" id="corresp2"></a><sup><a href="#autor2">2</a></sup> Jefe de Servicio.  Unidad de Terapia Intensiva Adultos, Hospital de Cl&iacute;nicas. FCM-UNA    <br>   <a name="corresp3" id="corresp3"></a><sup><a href="#autor3">3</a></sup> Jefe de Servicio  Urgencias. Hospital de Cl&iacute;nicas. FCM-UNA    <br>   <a name="corresp4" id="corresp4"></a><sup><a href="#autor4">4</a></sup> Sub jefa de Servicio.  Unidad de Terapia Intensiva Adultos, Hospital de Cl&iacute;nicas. FCM-UNA    <br>   <a name="corresp5" id="corresp5"></a><sup><a href="#autor5">5</a></sup> Jefe de sala.  Unidad de Terapia Intensiva Adultos, Hospital de Cl&iacute;nicas. FCM-UNA</font></p>     <p>&nbsp;</p>             ]]></body><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cannesson]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Musard]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Desebbe]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Boucau]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Simon]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Hénaine]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Lehot]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[The ability of stroke volume variations obtained with Vigileo/FloTrac system to monitor fluid responsiveness in mechanically ventilated patients]]></article-title>
<source><![CDATA[Anesth Analg]]></source>
<year>2009</year>
<month> F</month>
<day>eb</day>
<volume>108</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>513-7</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Benes]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Chytra]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Altmann]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Hluchy]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kasal]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Svitak]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Pradl]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Stepan]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Intraoperative fluid optimization using stroke volume variation in high risk surgical patients: results of prospective randomized study]]></article-title>
<source><![CDATA[Crit Care]]></source>
<year>2010</year>
<volume>14</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>118</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Michard]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Changes in arterial pressure during mechanical ventilation]]></article-title>
<source><![CDATA[Anesthesiology]]></source>
<year>2005</year>
<month> A</month>
<day>ug</day>
<volume>103</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>419-428</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Durairaj]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Schmidt]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Fluid therapy in resuscitated sepsis: less is more]]></article-title>
<source><![CDATA[Chest]]></source>
<year>2008</year>
<month> J</month>
<day>an</day>
<volume>133</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>252-63</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rivers]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Nguyen]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Havstad]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ressler]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Muzzin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Knoblich]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Early goal-directed therapy in the treatment of severe sepsis and septic shock]]></article-title>
<source><![CDATA[N Engl J Med.]]></source>
<year>2001</year>
<month> N</month>
<day>ov</day>
<volume>345</volume>
<numero>19</numero>
<issue>19</issue>
<page-range>1368-77</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Monnet]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Guérin]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Jozwiak]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bataille]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Julien]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Richard]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Teboul]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Pleth variability index is a weak predictor of fluid responsiveness in patients receiving norepinephrine]]></article-title>
<source><![CDATA[Br J Anaesth]]></source>
<year>2013</year>
<month> F</month>
<day>eb</day>
<volume>110</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>207-13</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Monnet]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Anguel]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Jozwiak]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Richard]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Teboul]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Third-generation FloTrac/Vigileo does not reliably track changes in cardiac output induced by norepinephrine in critically ill patients]]></article-title>
<source><![CDATA[Br J Anaesth.]]></source>
<year>2012</year>
<month> A</month>
<day>pr</day>
<volume>108</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>615-22</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
