<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2307-3349</journal-id>
<journal-title><![CDATA[Revista de salud publica del Paraguay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. salud publica Parag.]]></abbrev-journal-title>
<issn>2307-3349</issn>
<publisher>
<publisher-name><![CDATA[INSTITUTO NACIONAL DE SALUD - MSP Y BS]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2307-33492019000100073</article-id>
<article-id pub-id-type="doi">10.18004/rspp.2019.junio.73-80</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización epidemiológica y molecular de la Hepatitis C en la población que acudió al Laboratorio Central de Salud Pública, Paraguay 2013-2018]]></article-title>
<article-title xml:lang="en"><![CDATA[Epidemiological and molecular characterization of Hepatitis C in the population that went to the Central Laboratory of Public Health, Paraguay 2013-2018]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Olmedo]]></surname>
<given-names><![CDATA[Gladys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nagai]]></surname>
<given-names><![CDATA[Minako]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sugastti]]></surname>
<given-names><![CDATA[Ana Liz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Domingo]]></surname>
<given-names><![CDATA[Avalos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bobadilla]]></surname>
<given-names><![CDATA[María Liz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villagra]]></surname>
<given-names><![CDATA[Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Ministerio de Salud Pública y Bienestar Social Laboratorio Central de Salud Pública ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Ministerio de Salud Pública y Bienestar Social Hospital Regional de Caacupé ]]></institution>
<addr-line><![CDATA[Caacupé ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Ministerio de Salud Pública y Bienestar Social  ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<volume>9</volume>
<numero>1</numero>
<fpage>73</fpage>
<lpage>80</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2307-33492019000100073&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2307-33492019000100073&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2307-33492019000100073&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[ RESUMEN  Introducción: Las hepatitis causadas por el virus de la hepatitis C (VHC) se han transformado en uno de los principales problemas de enfermedades infecciosas emergentes, responsables del 80% de las hepatitis crónicas con posible evolución a cirrosis o carcinoma hepatocelular y ocasionando un alto costo para el sistema de salud.  Objetivo: Describir el perfil epidemiológico y los genotipos del VHC en pacientes que acudieron al Laboratorio Central de Salud Pública (LCSP).  Materiales y métodos: Estudio descriptivo; se incluyeron 162 pacientes con infección por Hepatitis C referidos al LCSP entre el 2013 y 2018, para seguimiento y/o genotipificación. Se les realizó la amplificación del genoma mediante la técnica reacción en cadena de la polimerasa en tiempo real previa transcripción reversa (RT-PCR). A una submuestra con PCR detectable y carga viral &gt;500 UI/ml se determinó el genotipo(n=52).  Resultados: La media de edad fue de 44,2 ±15,6 años, el 52,5% eran hombres. El 8,02% presentaron carga viral alta, 32,09 % baja y 59,87 % indetectable. La distribución de genotipos fue la siguiente: 61,5 % genotipo 1 (28,1% 1a, 53,1% 1b y 18,8% genotipo 1 sin subtipificación), 15,4% genotipo 2, 15,4% genotipo 3 y 7,7% genotipo 4.  Conclusiones: El presente trabajo muestra la importancia de la implementación de técnicas moleculares aplicadas a la vigilancia epidemiológica de nuestro país de manera a establecer programas de detección temprana y seguimiento adecuado de los pacientes, ya que la caracterización genotípica ayuda a determinar lasestrategias terapéuticas más adecuadas y predecir la respuesta antiviral. Se confirma que el genotipo 1 es el que circula con mayor frecuencia, con alto predominio del subtipo 1b.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Hepatitis caused by the hepatitis C virus (HCV) has become one of the main problems of emerging infectious diseases, responsible for 80% of chronic hepatitis with possible evolution to cirrhosis or hepatocellular carcinoma and causing a high cost for the health system.  Objective: To describe the epidemiological profile and the genotypes of HCV in patients who attended the Central Public Health Laboratory (LCSP).  Materials and methods: Descriptive study; included 162 patients with Hepatitis C infection referred to the LCSP between 2013 and 2018, for follow-up and / or genotyping. Genome amplification was performed using the polymerase chain reaction technique in real time prior to reverse transcription (RT-PCR). To a subsample with detectable PCR and viral load&gt; 500 IU / ml, the genotype was determined (n = 52).  Results: The mean age was 44.2 ± 15.6 years, 52.5% were men. The 8.02% had high viral load, 32.09% low and 59.87% undetectable. The genotype distribution was as follows: 61.5% genotype 1 (28.1% 1a, 53.1% 1b and 18.8% genotype 1 without subtyping), 15.4% genotype 2, 15.4% genotype 3 and 7.7% genotype 4.  Conclusions: The present work shows the importance of the implementation of molecular techniques applied to the epidemiological surveillance of our country in order to establish programs of early detection and adequate monitoring of patients, since genotypic characterization helps to determine the most appropriate therapeutic strategies and predict the antiviral response. It is confirmed that genotype 1 is the one that circulates more frequently, with a high predominance of subtype 1b.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Biología Molecular]]></kwd>
<kwd lng="es"><![CDATA[Hepatitis C]]></kwd>
<kwd lng="es"><![CDATA[Genotipo]]></kwd>
<kwd lng="es"><![CDATA[Epidemiología Molecular]]></kwd>
<kwd lng="es"><![CDATA[Paraguay.]]></kwd>
<kwd lng="en"><![CDATA[Molecular Biology]]></kwd>
<kwd lng="en"><![CDATA[Hepatitis C]]></kwd>
<kwd lng="en"><![CDATA[Genotype]]></kwd>
<kwd lng="en"><![CDATA[Molecular Epidemiology]]></kwd>
<kwd lng="en"><![CDATA[Paraguay]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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