<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2222-145X</journal-id>
<journal-title><![CDATA[Reportes científicos de la FACEN]]></journal-title>
<abbrev-journal-title><![CDATA[Rep. cient. FACEN]]></abbrev-journal-title>
<issn>2222-145X</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Ciencias Exactas y Naturales]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2222-145X2020000200048</article-id>
<article-id pub-id-type="doi">10.18004/rcfacen2020.11.02.48</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Determinación de di(2-etilhexil) adipato en aguas del lago Ypacarai por microextraccion líquido- líquido dispersiva]]></article-title>
<article-title xml:lang="en"><![CDATA[Determination of di(2-etilhexil) adipate in waters of lake Ypacarai by dispersive liquid-liquid microextraction]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Bonet]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López Arias]]></surname>
<given-names><![CDATA[Tomás]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Benítez Villalba]]></surname>
<given-names><![CDATA[Julio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Exactas y Naturales Dpto. de Química]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Exactas y Naturales 2Dpto. de Biotecnología,]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>11</volume>
<numero>2</numero>
<fpage>48</fpage>
<lpage>55</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2222-145X2020000200048&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2222-145X2020000200048&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2222-145X2020000200048&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: El lago Ypacaraí es un valioso recurso hídrico del Paraguay, es el lago más grande del país y es conocido internacionalmente a través de la música y el turismo. El gran crecimiento demográfico y las actividades antro- pogénicas desarrolladas en su cuenca han causado su contaminación y degradación ambiental en los últimos años. El objetivo de este trabajo fue cuantificar di(2-etilhexil) adipato (DEHA) en aguas del lago Ypacaraí, aplicando un método analítico desarrollado y validado. Dentro de la metodología analítica se aplicó la técnica de microextracción líquido-líquido dispersiva (DLLME) optimizada mediante un diseño experimental multivariante. La validación del método analítico se realizó evaluando cada una de las características de desempeño siguiendo los lineamientos de la guía Eurachem 2014. La metodología desarrollada optimizada y validada se aplicó correctamente a la determinación de DEHA en las aguas del lago Ypacaraí. Los límites de detección LOD y cuantificación LOQ fueron 0,004 mg.L-1 y 0,014 mg.L-1 respectivamente. La precisión del método evaluada mediante la repetibilidad y precisión intermedia fue de 2,37 % y 3,78 % y una recuperación 87,14 % al LOQ y 97,62 % a 0,3 mg.L-1. Los resultados comprueban la presencia de este contaminante en concentraciones entre 0,028 mg.L-1 y 0,603 mg.L-1. El método analítico fue desarrollado, optimizado y validado con éxito y posibilitó la correcta cuantificación del compuesto DEHA en aguas superficiales del lago Ypacaraí.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: The Ypacaraí Lake is a valuable water resource of Paraguay, it is the largest lake in the country and is known internationally through the music and tourism. The great demographic growth and anthropogenic activi- ties developed in its basin have caused its contamination and environmental degradation in recent years. The objective of this work was to develop and validate a method for the determination of di(2-ethylhexyl) adipate (DEHA) in its surface waters. The liquid-liquid dispersive microextraction technique (DLLME) optimized by means of a multivariate experimental design was used within the analytical methodology. The validation of the analytical method was carried out an evaluation of each of the characteristics of a performance following the guidelines of the Eurachem 2014 guide. The developed, optimized and validated methodology also applies to the determination of DEHA in the waters of Ypacaraí Lake. The limit of detection LOD and limit of quantification LOQ were 0.004 mg.L-1 and 0.014 mg.L-1 respectively. The precision of the method evaluated by repeatability and intermediate precision was 2.37 % and 3.78 % and 87.14 % of recovery at LOQ level and 97.62 % at 0.3 mg.L-1. The results include the presence of this contaminant in them between 0.028 mg.L-1 and 0.603 mg.L-1. The analytical method was successfully developed, optimized and validated and it enabled the correct quantification of the DEHA compound in the surface waters of Ypacaraí Lake.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[aguas superficiales]]></kwd>
<kwd lng="es"><![CDATA[di(2-etilhexil) adipato]]></kwd>
<kwd lng="es"><![CDATA[diseño experimental multivariante]]></kwd>
<kwd lng="es"><![CDATA[microextracción líquido-líquido dispersiva.]]></kwd>
<kwd lng="en"><![CDATA[surface waters]]></kwd>
<kwd lng="en"><![CDATA[di(2-ethylhexyl)adipate]]></kwd>
<kwd lng="en"><![CDATA[multivariate experimental design]]></kwd>
<kwd lng="en"><![CDATA[dispersive liquid-liquid microextraction.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aragón]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Marcé]]></surname>
<given-names><![CDATA[R.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Borrull]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Determination of phthalates and organophosphate esters in particulated material from harbour air samples by pressurised liquid extraction and gas chromatography-mass spectrometry.]]></article-title>
<source><![CDATA[Talanta]]></source>
<year>2012</year>
<volume>101</volume>
<page-range>473-8</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barnabé]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Beauchesne]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Cooper]]></surname>
<given-names><![CDATA[D.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Nicell]]></surname>
<given-names><![CDATA[J.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Plasticizers and their degradation products in the process streams of a large urban physicochemical sewage treatment plant.]]></article-title>
<source><![CDATA[Water Research]]></source>
<year>2008</year>
<volume>42</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>153-62</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Farajzadeh]]></surname>
<given-names><![CDATA[M.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Bahram]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Jönsson]]></surname>
<given-names><![CDATA[J.Å.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dispersive liquid-liquid micro extraction followed by high-performance liquid chromatography-diode array detection as an efficient and sensitive technique for determination of antioxidants.]]></article-title>
<source><![CDATA[Analytica Chimica Acta]]></source>
<year>2007</year>
<volume>591</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>69-79.</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Farajzadeh]]></surname>
<given-names><![CDATA[M. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Khoshmaram]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Development of dispersive liquid-liquid microextraction technique using ternary solvents mixture followed by heating for the rapid and sensitive analysis of phthalate esters and di(2-ethylhexyl) adipate.]]></article-title>
<source><![CDATA[Journal of Chromatography A,]]></source>
<year>2015</year>
<volume>1379</volume>
<page-range>24-33</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Farré]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Barceló]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fate and toxicity of emerging pollutants, their metabolites and transformation products in the aquatic environment.]]></article-title>
<source><![CDATA[Trends in Analytical Chemistry]]></source>
<year>2008</year>
<volume>27</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>991-1007</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fatecha]]></surname>
<given-names><![CDATA[D.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Rasche]]></surname>
<given-names><![CDATA[J.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Cabral]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Ojeda]]></surname>
<given-names><![CDATA[J.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Coppo]]></surname>
<given-names><![CDATA[J.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Alves Neto]]></surname>
<given-names><![CDATA[A.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Lorezetti]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Watanake]]></surname>
<given-names><![CDATA[C.K.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Rissato]]></surname>
<given-names><![CDATA[B.B.]]></given-names>
</name>
<name>
<surname><![CDATA[Belmonte]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phosphorus fractionation in sediments of the Ypacarai lake basin.]]></article-title>
<source><![CDATA[African Journal of Agricultural Research,]]></source>
<year>2016</year>
<volume>11</volume>
<numero>35</numero>
<issue>35</issue>
<page-range>3360-3365.</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gil]]></surname>
<given-names><![CDATA[M.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Soto]]></surname>
<given-names><![CDATA[A.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Usma]]></surname>
<given-names><![CDATA[J.I.]]></given-names>
</name>
<name>
<surname><![CDATA[Gutiérrez]]></surname>
<given-names><![CDATA[O.D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Contaminantes emergentes en aguas, efectos y posibles tratamientos.]]></article-title>
<source><![CDATA[Producción + Limpia,]]></source>
<year>2012</year>
<volume>7</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>52-73</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Han]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Di(2-ethylhexyl) adipate (DEHA) detection in Antarctic krill (Euphasia superba Dana).]]></article-title>
<source><![CDATA[Polar Research,]]></source>
<year>2018</year>
<volume>37</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1457395</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lo Turco]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Di Bella]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Potortì]]></surname>
<given-names><![CDATA[A. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Fede]]></surname>
<given-names><![CDATA[M. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Dugo]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Determination of plasticizer residues in tea by solid phase extraction-gas chromatography-mass spectrometry.]]></article-title>
<source><![CDATA[European Food Research and Technology,]]></source>
<year>2015</year>
<volume>240</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>451-8</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[López Moreira.]]></surname>
<given-names><![CDATA[G.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Hinegk]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Salvadore]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Zolezzi]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Hölker]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Monte Domecq]]></surname>
<given-names><![CDATA[R.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Bocci]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Carrer]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[De Nat]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Escribá]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Benítez]]></surname>
<given-names><![CDATA[G.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ávalos]]></surname>
<given-names><![CDATA[C.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Peralta]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Insaurralde]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Mereles]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Sekatcheff]]></surname>
<given-names><![CDATA[J.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Wehrle]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Facetti-Masulli]]></surname>
<given-names><![CDATA[J.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Facetti]]></surname>
<given-names><![CDATA[J.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Toffolon]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Eutrophication, research and management history of the shallow Ypacaraí lake (Paraguay).]]></article-title>
<source><![CDATA[Sustainability]]></source>
<year>2018</year>
<volume>10</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>2426</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Magnusson]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Örnemark]]></surname>
<given-names><![CDATA[U.]]></given-names>
</name>
</person-group>
<source><![CDATA[Eurachem guide: The Fitness for Purpose of Analytical Methods: A Laboratory Guide to Method Validation and Related Topics.]]></source>
<year>2014</year>
<edition>2</edition>
<page-range>62</page-range><publisher-name><![CDATA[Middlesex: Eurachem Method Validation Working Group]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rezaee]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Assadi]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Milani Hosseini]]></surname>
<given-names><![CDATA[M.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Aghaee]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Ahmadi]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Berijani]]></surname>
<given-names><![CDATA[S. (]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Determination of organic compounds in water using dispersive liquid-liquid mi-croextraction.]]></article-title>
<source><![CDATA[Journal of Chromatography A,]]></source>
<year>2006</year>
<volume>1116</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-9.</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="book">
<collab>EPA</collab>
<source><![CDATA[EPA 606 Methods for the Determination of Organic Compounds in Drinking Water - Supplement III (EPA/600/R-95-131).]]></source>
<year>1995</year>
<page-range>584</page-range><publisher-loc><![CDATA[Washington ]]></publisher-loc>
<publisher-name><![CDATA[United States Environmental Protection Agency.]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="book">
<collab>EPA</collab>
<source><![CDATA[Drinking Water Standards and Health Advisorie tables. 2018 ed.]]></source>
<year>2018</year>
<page-range>12</page-range><publisher-loc><![CDATA[Washington ]]></publisher-loc>
<publisher-name><![CDATA[United States Environmental Protection Agency.]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="book">
<collab>United Nations Environment Programme UNEP;.</collab>
<source><![CDATA[Bis(2-ethylhexyl)adipate - SIDS Initial Assessment Report For SIAM 10.]]></source>
<year>2000</year>
<page-range>78</page-range><publisher-loc><![CDATA[Nairobi ]]></publisher-loc>
<publisher-name><![CDATA[UNEP Publications.]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[S.N.]]></given-names>
</name>
<name>
<surname><![CDATA[Moody]]></surname>
<given-names><![CDATA[R.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Aikawa]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Yip]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In Vitro Dermal Absorption of Di(2-ethylhexyl) adipate (DEHA) in a rollon deodorant using human skin.]]></article-title>
<source><![CDATA[Journal of Toxicology and Environmental Health, Part A,]]></source>
<year>2013</year>
<volume>76</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>157-66</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
