<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2222-145X</journal-id>
<journal-title><![CDATA[Reportes científicos de la FACEN]]></journal-title>
<abbrev-journal-title><![CDATA[Rep. cient. FACEN]]></abbrev-journal-title>
<issn>2222-145X</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Ciencias Exactas y Naturales]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2222-145X2018000100051</article-id>
<article-id pub-id-type="doi">10.18004/rcfacen.2018.9.1.51</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Validación de un método de análisis de benzofenonas en muestras de suelo por extracción con líquidos presurizados y cromatografía líquida acoplada a espectrometría de masas en tándem]]></article-title>
<article-title xml:lang="en"><![CDATA[Validation of an analysis method for benzophenones in a soil sample through pressurized liquid extraction and liquid chromatograph coupled to tandem mass spectrometry]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Benítez-Villalba]]></surname>
<given-names><![CDATA[Julio César]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dorival-García]]></surname>
<given-names><![CDATA[Noemí]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villalba-Villalba]]></surname>
<given-names><![CDATA[Nadia Mabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vílchez]]></surname>
<given-names><![CDATA[José Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Exactas y Naturales ]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Granada Departamento de Química Analítica ]]></institution>
<addr-line><![CDATA[Granada ]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<volume>9</volume>
<numero>1</numero>
<fpage>51</fpage>
<lpage>63</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2222-145X2018000100051&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2222-145X2018000100051&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2222-145X2018000100051&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: En este trabajo de investigación se ha desarrollado y validado una metodología analítica para la determinación y cuantificación de una familia de benzofenonas en muestras de suelo, estos compuestos provienen de procesos industriales, de síntesis orgánica, generalmente cosméticos y protectores solares, que no son eliminados durante el tratamiento de las aguas residuales; se han optimizado las variables de extracción utilizando la técnica de Extracción por Líquidos Presurizados (PLE), los compuestos fueron detectados y cuantificados mediante un cromatógrafo de líquido acoplada a espectrometría de masas en tándem (MS/MS, QqQ), operando en modo ESI positivo y negativo, en modo SRM (monitorización de la reacción seleccionada) con separación de los analitos en menos de 6 minutos, utilizando la Benzofenona deuterado (BP-d-10) como patrón interno; obteniendo recuperaciones de los analitos comprendidas entre el 97,0% y 101,0% con el método. Los límites de detección fueron de 0,05 a 0,90 ng g-1 y el límite de cuantificación entre 0,16 a 2,70 ng g-1. Se ha demostrado que el método analítico es preciso, sensible, selectivo y exacto, con límites de detección y cuantificación suficientemente bajos para emplear este método analítico en la detección y cuantificación de estos compuestos en esta muestra medioambiental. Este método ofrece una innovación científica, ya que son pocos los métodos publicados sobre el estudio de estos microcontaminantes en suelos agrícolas como matriz estudiada.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: In this research work an analytical methodology has been developed and validated for the determination and quantification of a family of benzophenones in soil samples, these compounds come from industrial processes, organic synthesis, cosmetics and sunscreens, which are not eliminated during the Treatment of waste water; The extraction variables have been optimized using the Pressurized Liquid Extraction (PLE) technique, the compounds were detected and quantified by a liquid chromatograph coupled to tandem mass spectrometry (MS / MS, QqQ), operating in positive ESI mode and negative, in SRM mode (monitoring of the selected reaction) with analyte separation in less than 6 minutes, using deuterated Benzophenone (BP-d-10) as internal standard; obtaining recoveries of analytes between 97.0% and 101.0% with the method. The detection limits were 0.05 to 0.90 ng g-1 and the quantification limit between 0.16 to 2.70 ng g-1. The analytical method has been detected is precise, sensitive, selective and accurate, with detection and quantification limits sufficiently low to detect this analytical method in the detection and quantification of these compounds in this environmental sample. This method offers a scientific innovation, since there are few published methods on the study of these microcontaminants in agricultural soils as a matrix studied.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Benzofenonas]]></kwd>
<kwd lng="es"><![CDATA[espectrometría de masas]]></kwd>
<kwd lng="es"><![CDATA[contaminantes emergentes]]></kwd>
<kwd lng="es"><![CDATA[disruptor endócrino]]></kwd>
<kwd lng="en"><![CDATA[Benzophenones]]></kwd>
<kwd lng="en"><![CDATA[mass spectrometry]]></kwd>
<kwd lng="en"><![CDATA[emerging contaminants]]></kwd>
<kwd lng="en"><![CDATA[endocrine disruptor]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Benítez&#8208;Villalba]]></surname>
<given-names><![CDATA[J.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Zafra&#8208;Gómez]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Dorival&#8208;García]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Camino&#8208;Sánchez]]></surname>
<given-names><![CDATA[J.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Cantarero]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Vílchez]]></surname>
<given-names><![CDATA[J. L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ultra-performance liquid chromatography MS/MS method for the determination of parabens in compost from sewage sludge: Comparison of the efficiency of two extraction techniques.]]></article-title>
<source><![CDATA[Journal of Separation Science]]></source>
<year>2013</year>
<volume>16</volume>
<page-range>2635-45</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Benítez-Villalba]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Zafra-Gómez]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Juárez-Giménez]]></surname>
<given-names><![CDATA[M.J.B.]]></given-names>
</name>
<name>
<surname><![CDATA[Dorival-Garcia]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Ferreira-Benítez]]></surname>
<given-names><![CDATA[F. P.]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez-Bonet]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Vílchez]]></surname>
<given-names><![CDATA[J.L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Biodegradation of thebenzophenone-3 in agricultural soils amended with compost from urban waste- water treatmentplants.]]></article-title>
<source><![CDATA[Reportes Científicos de la FACEN]]></source>
<year>2017</year>
<page-range>79-88.</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bush]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antimicrobial agents.]]></article-title>
<source><![CDATA[Current Opinion in Chemical Biology]]></source>
<year>1997</year>
<volume>1</volume>
<page-range>162-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Calamari]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Assessment of persistence and bioaccumulating chemicals in the aquatic Environment.]]></article-title>
<source><![CDATA[Journal of Pharmacy and Pharmacology]]></source>
<year>1995</year>
<volume>37</volume>
<page-range>1-12.</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Canosa]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Perez-Palacios]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Garrido-Lopez]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Tena]]></surname>
<given-names><![CDATA[M.T.]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Rubi]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Cela]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pressurized liquid extraction with in-cell clean-up followed by gas chromatography - tandem mass spectrometry for the selective determination of parabens and TCS in indoor dust.]]></article-title>
<source><![CDATA[Journal of Chromatography A]]></source>
<year>2007</year>
<volume>1161</volume>
<page-range>105-112.</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cunningham]]></surname>
<given-names><![CDATA[V.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Buzby]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Hutchinson]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Mastrocco]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Parke]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Roden]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of human pharmaceuticals on aquatic life: next steps.]]></article-title>
<source><![CDATA[Environmental Science and Tecnology]]></source>
<year>2006</year>
<volume>40</volume>
<page-range>3456-3465.</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Díaz-Cruz]]></surname>
<given-names><![CDATA[M.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Barceló]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Determination of antimicrobial residues and metabolites in the aquatic environment by liquid chromatography tandem mass spectrometry.]]></article-title>
<source><![CDATA[Analytical and Bioanalytical Chemistry]]></source>
<year>2006</year>
<volume>386</volume>
<page-range>973-985.</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Doughton]]></surname>
<given-names><![CDATA[C.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Ternes]]></surname>
<given-names><![CDATA[T.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pharmaceuticals and personal care products in the Environment: Agents of subtle change.]]></article-title>
<source><![CDATA[Environmental Health Perspectives]]></source>
<year>1999</year>
<volume>107</volume>
<page-range>907-938.</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<collab>European Commission.</collab>
<article-title xml:lang=""><![CDATA[European workshop on the impact of endocrine disruptors on human health and wildlife.]]></article-title>
<source><![CDATA[DG XII Weybridge Environment and Climate Research Programme Report Europe,]]></source>
<year>1996</year>
<volume>17549</volume>
<page-range>1-125.</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fent]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Weston]]></surname>
<given-names><![CDATA[A.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Caminada]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ecotoxicology of human pharmaceuticals.]]></article-title>
<source><![CDATA[Aquatic Toxicology]]></source>
<year>2006</year>
<volume>76</volume>
<page-range>122-59</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jemba]]></surname>
<given-names><![CDATA[P.K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Excretion and ecotoxicity of pharmaceutical and personal care products in the environment.]]></article-title>
<source><![CDATA[Ecotoxicology and Environment,]]></source>
<year>2006</year>
<volume>63</volume>
<page-range>113-130.</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jeon]]></surname>
<given-names><![CDATA[H.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Chung Y.]]></surname>
<given-names><![CDATA[Ryu J.C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Simultaneous determination of benzophenone-type UV filters in water and soil by gas chromatography-mass spectrometry.]]></article-title>
<source><![CDATA[Journal of Chromatography A]]></source>
<year>2006</year>
<volume>1131:</volume>
<page-range>192-202.</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Khetan]]></surname>
<given-names><![CDATA[S.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Collins]]></surname>
<given-names><![CDATA[T.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Human pharmaceuticals in the aquatic environment: A challenge to green chemistry.]]></article-title>
<source><![CDATA[Chemical Reviews]]></source>
<year>2007</year>
<volume>107</volume>
<page-range>2319-64</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kotnik]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Kosjek]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Krajnc]]></surname>
<given-names><![CDATA[U.]]></given-names>
</name>
<name>
<surname><![CDATA[Heath]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Trace analysis of benzophenone- derived compounds in surface waters and sediments using solid-phase extraction and microwave-assisted extraction followed by gas chromatography-mass spectrometry.]]></article-title>
<source><![CDATA[Analytical and Bioanalytical Chemistry]]></source>
<year>2014</year>
<volume>13</volume>
<page-range>3179-90</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kummerer]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Significance of antibiotics in the environment.]]></article-title>
<source><![CDATA[Journal of Antimicrobial Chemotherapy,]]></source>
<year>2003</year>
<volume>52</volume>
<page-range>5-7</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kummerer]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Resistance in the environment.]]></article-title>
<source><![CDATA[Journal of Antimicrobial Chemo therapy,]]></source>
<year>2004</year>
<volume>54</volume>
<page-range>311-20</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Petrovic]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Hernando]]></surname>
<given-names><![CDATA[M.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz-Cruz]]></surname>
<given-names><![CDATA[M.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Barceló]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Liquid chromatography- tandem mass spectrometry for the analysis of pharmaceutical residues in environmental samples: A Review.]]></article-title>
<source><![CDATA[Journal of Chromatography A]]></source>
<year>2005</year>
<volume>1067:</volume>
<page-range>1-14</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Richardson]]></surname>
<given-names><![CDATA[M.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Bowron]]></surname>
<given-names><![CDATA[J.M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The fate of pharmaceutical chemical in the aquatic environment.]]></article-title>
<source><![CDATA[Journal of Pharmacy and Pharmacology]]></source>
<year>1985</year>
<volume>37:</volume>
<page-range>1-12</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez-Brunete]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Miguel]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Albero]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Tadeo]]></surname>
<given-names><![CDATA[J.L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Analysis of salicylate and benzophenone-type UV filters in soils and sediments by simultaneous extraction cleanup and gas chromatography-mass spectrometry.]]></article-title>
<source><![CDATA[Journal Chromatography A]]></source>
<year>2011</year>
<volume>1218</volume>
<page-range>4291-4298.</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sautour]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Rouget]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Dantigny]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Divies]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Bensoussan]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Application of Doehlert design to determine the combined effects of temperature, water activity and pH on conidial germination of penicillium chrysogenum.]]></article-title>
<source><![CDATA[Journal of Applied Microbiology,]]></source>
<year>2001</year>
<volume>91</volume>
<page-range>900-906.</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
