<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2072-8174</journal-id>
<journal-title><![CDATA[Revista del Nacional (Itauguá)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Nac. (Itauguá)]]></abbrev-journal-title>
<issn>2072-8174</issn>
<publisher>
<publisher-name><![CDATA[Hospital Nacional (Itauguá)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2072-81742020000200124</article-id>
<article-id pub-id-type="doi">10.18004/rdn2020.dic.02.124.129</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Nefropatía C1q: diagnóstico inusual de síndrome nefrótico en la infancia. Reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[C1q nephropathy: unusual diagnosis of nephrotic syndrome in childhood. Case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Basabe Ochoa]]></surname>
<given-names><![CDATA[Aura Mearlyn]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Troche Hermosilla]]></surname>
<given-names><![CDATA[Avelina Victoria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Pico]]></surname>
<given-names><![CDATA[Marlene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Previsión Social Hospital Central &#8220;Dr. Emilio Cubas&#8221; Servicio de Nefrología, Unidad de Nefrología Pediátrica]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>12</volume>
<numero>2</numero>
<fpage>124</fpage>
<lpage>129</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2072-81742020000200124&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2072-81742020000200124&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2072-81742020000200124&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La nefropatía C1q es una glomerulopatía poco comprendida y subdiagnosticada. Se define por un patrón de inmunfluorescencia dominante o codominante de positividad para C1q, con depósitos electrodensos en mesangio, en ausencia de serología y clínica de lupus eritematoso sistémico. Clínicamente se manifiesta con proteinuria severa o de rango nefrótico, en ocasiones hematuria e hipertensión arterial. Histológicamente presenta morfología variada. Usualmente se manifiesta como síndrome nefrótico corticodependiente o corticoresistente con mala respuesta al tratamiento inmunosupresor y evolución a la cronicidad. Se presenta el caso clínico de un niño diagnosticado con nefropatía C1q, a quien se indicó biopsia renal por cuadro de síndrome nefrótico corticorresistente, con serología negativa y ausencia de datos clínicos para lupus eritematoso sistémico. La intervención oportuna y el manejo temprano permiten enlentecer su evolución a la cronicidad]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT C1q nephropathy is a poorly understood and underdiagnosed glomerulopathy. It is defined by a dominant or codominant immunfluorescence pattern of C1q positivity, with electrodense deposits in the mesangium, in the absence of serology and symptoms of systemic lupus erythematosus. Clinically, it manifests with severe proteinuria or nephrotic range, occasionally hematuria and arterial hypertension. Histologically it presents varied morphology. It usually manifests as a corticodependent or cortico-resistant nephrotic syndrome with poor response to immunosuppressive treatment and evolution to chronicity. We present the clinical case of a child diagnosed with C1q nephropathy, who underwent a renal biopsy due to corticosteroid-resistant nephrotic syndrome, with negative serology and absence of clinical data for systemic lupus erythematosus. Timely intervention and early management slow down its progression to chronicity]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[nefropatía C1q]]></kwd>
<kwd lng="es"><![CDATA[síndrome nefrótico]]></kwd>
<kwd lng="es"><![CDATA[proteinuria]]></kwd>
<kwd lng="es"><![CDATA[hematuria]]></kwd>
<kwd lng="en"><![CDATA[C1q nephropathy]]></kwd>
<kwd lng="en"><![CDATA[nephrotic syndrome]]></kwd>
<kwd lng="en"><![CDATA[proteinuria]]></kwd>
<kwd lng="en"><![CDATA[hematuria]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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