<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2072-8174</journal-id>
<journal-title><![CDATA[Revista del Nacional (Itauguá)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Nac. (Itauguá)]]></abbrev-journal-title>
<issn>2072-8174</issn>
<publisher>
<publisher-name><![CDATA[Hospital Nacional (Itauguá)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2072-81742019000200041</article-id>
<article-id pub-id-type="doi">10.18004/rdn2019.0011.02.041-050</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Variabilidad biológica e histológica del cáncer de mama]]></article-title>
<article-title xml:lang="en"><![CDATA[Biological and histological variability of breast cancer]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cabrera]]></surname>
<given-names><![CDATA[Marcos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aparicio de Real]]></surname>
<given-names><![CDATA[Celeste]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción, Facultad de Ciencias Médicas Post Grado en Gineco Obstetricia Unidad Académica del Hospital Materno Infantil San Pablo]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>11</volume>
<numero>2</numero>
<fpage>41</fpage>
<lpage>50</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2072-81742019000200041&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2072-81742019000200041&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2072-81742019000200041&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  el cáncer de mama en la mujer es una de las neoplasias más estudiadas. Sus factores de riesgo se encuentran bien identificados y es una de las patologías con más clasificaciones a lo largo de la historia de la Medicina.  Objetivos:  describir las características clínicas del cáncer de mama en el Hospital San Pablo (Asunción, Paraguay) en periodo 2016-2017.  Metodología:  diseño observacional descriptivo retrospectivo de revisión de expedientes médicos de pacientes con confirmación histológica de cáncer de mama del Hospital San Pablo (Asunción, Paraguay) en periodo 2016-2017.  Resultados:  se incluyeron 75 casos. La edad media fue 52±11 años. El tipo histológico más frecuente fue el ductal infiltrante con un grado moderado de diferenciación al momento del diagnóstico. El estadio clínico al momento del diagnóstico más frecuente fue el estadio II y el tipo biológico luminal A, resultó el más frecuente. El tratamiento instaurado en la mayoría de los casos fue la mastectomía radical modificada.  Conclusiones:  el cáncer de mama más frecuente fue el ductal infiltrante, estadio II. La mastectomía radical modificada fue el tratamiento más utilizado.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: breast cancer in women is one of the most studied malignancies. Its risk factors are well identified and it´s one of the pathologies with more classifications throughout the history of Medicine.  Objectives: to describe the clinical characteristics of breast cancer in the San Pablo Hospital (Asunción, Paraguay) the period of 2016-2017.  Methodology: retrospective descriptive observational design of medical records revision of patients with histological confirmation of breast cancer from San Pablo Hospital (Asunción, Paraguay) in the period of 2016-2017.  Results: 75 cases were included. The mean age was 52 ± 11 years. The most frequent histological type was the infiltrating ductal with a moderate degree of differentiation at the time of diagnosis. The clinical stage at the time of the most frequent diagnosis was stage II and the luminal biological type A was the most frequent. The treatment established in most cases were modified radical mastectomy.  Conclusions: the most frequent breast cancer was infiltrating ductal, stage II. Modified radical mastectomy was the most used treatment.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[neoplasias de la mama]]></kwd>
<kwd lng="es"><![CDATA[carcinoma ductal de mama]]></kwd>
<kwd lng="es"><![CDATA[mastectomía]]></kwd>
<kwd lng="en"><![CDATA[breast malignancies]]></kwd>
<kwd lng="en"><![CDATA[ductal carcinoma of the breast]]></kwd>
<kwd lng="en"><![CDATA[mastectomy]]></kwd>
</kwd-group>
</article-meta>
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