<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1816-8949</journal-id>
<journal-title><![CDATA[Anales de la Facultad de Ciencias Médicas (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[An. Fac. Cienc. Méd. (Asunción)]]></abbrev-journal-title>
<issn>1816-8949</issn>
<publisher>
<publisher-name><![CDATA[EFACIM. Editorial de la Facultad de Ciencias Médicas - Universidad Nacional de Asunción]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1816-89492024000200072</article-id>
<article-id pub-id-type="doi">10.18004/anales/2024.057.02.72</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Necrobiosis lipoídica en paciente no diabética. A propósito de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Necrobiosis lipoídica in non- diabetic patient. Report of a case]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ocampos Montiel]]></surname>
<given-names><![CDATA[Sara Elisa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Da ponte Rojas]]></surname>
<given-names><![CDATA[María Noemi]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mongelós Ortiz]]></surname>
<given-names><![CDATA[Andrea Belén]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Florentín Mancía]]></surname>
<given-names><![CDATA[Sandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aldama Caballero]]></surname>
<given-names><![CDATA[Arnaldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas, Hospital de Clínicas Cátedra de Dermatología]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2024</year>
</pub-date>
<volume>57</volume>
<numero>2</numero>
<fpage>72</fpage>
<lpage>76</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1816-89492024000200072&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1816-89492024000200072&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1816-89492024000200072&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La necrobiosis lipoídica es una enfermedad granulomatosa crónica de la piel de etiología desconocida. Se caracteriza por placas inflamatorias amarronadas amarillentas con bordes indurados y centro atrófico, localizada en la cara anterior de las piernas. Tiene predominancia por el sexo femenino y su asociación con la diabetes es variable. Presentamos el caso de una mujer joven de 32 años, sin patologías previas, que desarrolla lesiones de apariencia cicatricial en ambos miembros inferiores tras accidente de tránsito. Se plantea el diagnóstico de necrobiosis lipoídica que se confirma por la anatomía patológica. Se inició tratamiento con corticoides, tacrolimus tópicos y se programa sesiones de fototerapia según evolución.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Necrobiosis Lipoídica (NL) is a chronic granulomatous disease of unknown etiology. It is characterized with yellowish-brown plaques with central skin atrophy and indurated borders. It has a predominance in female, and it has variable association with diabetes mellitus. We report a case of a young woman of 32 years old with no comorbities known but she did had a vehicular accident that leave her scars in both legs, therefore the plaques began to appear. We confirmed diagnosis with skin biopsy. She began treatment with topical corticosteroids, tacrolimus and phototerapy was schedule according to progress.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Necrobiosis lipoídica]]></kwd>
<kwd lng="es"><![CDATA[Diabetes]]></kwd>
<kwd lng="es"><![CDATA[placas amarronadas o amarillentas]]></kwd>
<kwd lng="en"><![CDATA[Necrobiosis Lipoídica]]></kwd>
<kwd lng="en"><![CDATA[Diabetes]]></kwd>
<kwd lng="en"><![CDATA[yellowish-brown plaques.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Erfurt-Berge]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Heusinger]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Reinboldt-Jockenhöfer]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Dissemond]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Renner]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comorbidity and therapeutic approaches in patients with necrobiosis lipoidica]]></article-title>
<source><![CDATA[Dermatology]]></source>
<year>2022</year>
<volume>238</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>148-55</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chiarpenello]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Baella]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Riccobene]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Strallnicoff]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Castagnani]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Necrobiosis lipoídica en paciente diabético tipo 1: Reporte de un caso]]></article-title>
<source><![CDATA[Rev Med Rosario]]></source>
<year>2014</year>
<volume>80</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>33-6</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Peckruhn]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Tittelbach]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Elsner]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Update: Treatment of necrobiosis lipoidica]]></article-title>
<source><![CDATA[J Dtsch Dermatol]]></source>
<year>2017</year>
<volume>15</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>151-7</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mistry]]></surname>
<given-names><![CDATA[BD]]></given-names>
</name>
<name>
<surname><![CDATA[Alavi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ali]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Mistry]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A systematic review of the relationship between glycemic control and necrobiosis lipoidica diabeticorum in patients with diabetes mellitus]]></article-title>
<source><![CDATA[Int J Dermatol]]></source>
<year>2017</year>
<volume>56</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1319-27</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mendes]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
<name>
<surname><![CDATA[Miot]]></surname>
<given-names><![CDATA[HA]]></given-names>
</name>
<name>
<surname><![CDATA[Haddad]]></surname>
<given-names><![CDATA[VJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diabetes mellitus and the skin]]></article-title>
<source><![CDATA[An Bras Dermatol]]></source>
<year>2017</year>
<volume>92</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>8-20</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marcoval]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez-Armayones]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Valentí-Medina]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Bonfill-Ortí]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez-Molina]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Necrobiosis lipoídica. Estudio descriptivo de 35 pacientes]]></article-title>
<source><![CDATA[Actas Dermosifiliogr]]></source>
<year>2015</year>
<volume>106</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>402-7</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pitarch]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Giner]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Periorbital Necrobiosis Lipoidica]]></article-title>
<source><![CDATA[Actas Dermo-Sifiliográficas (English Ed)]]></source>
<year>2013</year>
<volume>104</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>636-8</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Conde]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Avilés]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
<name>
<surname><![CDATA[Parra]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dermoscopy of Necrobiosis Lipoidica &#2845; Dermatoscopia de la necrobiosis lipoídica]]></article-title>
<source><![CDATA[Cart Cient]]></source>
<year>2013</year>
<page-range>534-7</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Di Prisco]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Lafuente de Leamus]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Necrobiosis lipoidica]]></article-title>
<source><![CDATA[Rev DEL Dep DERMATOLOGIA DEL Hosp Univ Caracas]]></source>
<year>2021</year>
<volume>96</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>59-70</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Burns]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Ukoha]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Necrobiosis lipoidica with rapid response to doxycycline]]></article-title>
<source><![CDATA[Pediatr Dermatol]]></source>
<year>2020</year>
<volume>37</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>981-2</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Erfurt-Berge]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Dissemond]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Schwede]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Seitz]]></surname>
<given-names><![CDATA[A-T]]></given-names>
</name>
<name>
<surname><![CDATA[Al Ghazal]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Wollina]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study]]></article-title>
<source><![CDATA[Eur J Dermatol]]></source>
<year>2015</year>
<volume>25</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>595-601</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hashemi]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[Brown-Joel]]></surname>
<given-names><![CDATA[ZO]]></given-names>
</name>
<name>
<surname><![CDATA[Tkachenko]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Nelson]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Noe]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
<name>
<surname><![CDATA[Imadojemu]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical features and comorbidities of patients with necrobiosis lipoidica with or without diabetes]]></article-title>
<source><![CDATA[JAMA Dermatol]]></source>
<year>2019</year>
<volume>155</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>455-9</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Puerta-Peña]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[García-Donoso]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Necrobiosis lipoidica: A complication of diabetes mellitus]]></article-title>
<source><![CDATA[Med Fam Semer]]></source>
<year>2020</year>
<volume>46</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>e51-2</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nunes de Mattos]]></surname>
<given-names><![CDATA[AB]]></given-names>
</name>
<name>
<surname><![CDATA[Brummer]]></surname>
<given-names><![CDATA[CF]]></given-names>
</name>
<name>
<surname><![CDATA[Funchal]]></surname>
<given-names><![CDATA[GDG]]></given-names>
</name>
<name>
<surname><![CDATA[Nunes]]></surname>
<given-names><![CDATA[DH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Perforating necrobiosis lipoidica: good response to adalimumab]]></article-title>
<source><![CDATA[An Bras Dermatol]]></source>
<year>2019</year>
<volume>94</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>769-71</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[YN]]></given-names>
</name>
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[HZ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Unilateral necrobiosis lipoidica of the flexor aspect of the lower leg]]></article-title>
<source><![CDATA[CMAJ]]></source>
<year>2020</year>
<volume>192</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Grillo]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Rodriguez-Muñoz]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[González-García]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Jaén]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Necrobiosis lipoidica]]></article-title>
<source><![CDATA[Aust Fam Physician]]></source>
<year>2014</year>
<volume>43</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>129-30</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Youssef]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Belhadjali]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Necrobiosis lipoidica-like cutaneous leishmaniasis]]></article-title>
<source><![CDATA[Pan Afr Med J]]></source>
<year>2014</year>
<volume>18</volume>
<page-range>28</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Koura-Nishura]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Yoneda]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Nakai]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Demitsu]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Kubota]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clearance of atypical facial necrobiosis lipoidica with tacrolimus ointment]]></article-title>
<source><![CDATA[J Eur Acad Dermatology Venereol]]></source>
<year>2016</year>
<volume>30</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>383-5</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Álvarez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Velázquez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Necrobiosis lipoídica abscedada: manifestación cutánea de la diabetes]]></article-title>
<source><![CDATA[Rev Salud y Soc]]></source>
<year>2021</year>
<volume>1</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
