<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1816-8949</journal-id>
<journal-title><![CDATA[Anales de la Facultad de Ciencias Médicas (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[An. Fac. Cienc. Méd. (Asunción)]]></abbrev-journal-title>
<issn>1816-8949</issn>
<publisher>
<publisher-name><![CDATA[EFACIM. Editorial de la Facultad de Ciencias Médicas - Universidad Nacional de Asunción]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1816-89492023000300084</article-id>
<article-id pub-id-type="doi">10.18004/anales/2023.056.03.84</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Sífilis maligna: comunicación de 2 casos en pacientes sin SIDA]]></article-title>
<article-title xml:lang="en"><![CDATA[Malignant syphilis: report of 2 cases in patients without AIDS]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aldama Caballero]]></surname>
<given-names><![CDATA[Arnaldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Elli]]></surname>
<given-names><![CDATA[María Melissa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montoya]]></surname>
<given-names><![CDATA[Camila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Cátedra de Dermatología]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Servicios de Dermatología y Anatomía Patológica]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>56</volume>
<numero>3</numero>
<fpage>84</fpage>
<lpage>88</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1816-89492023000300084&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1816-89492023000300084&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1816-89492023000300084&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La sífilis es una enfermedad polifacética que siempre requiere diagnósticos diferenciales. Una forma rara de la sífilis secundaria, es la llamada sífilis maligna caracterizada por lesiones ulcero necróticas cubiertas por gruesas costras de aspecto rupioide u ostráceo. Actualmente se observa principalmente en pacientes infectados por el virus de la inmunodeficiencia humana, pero anteriormente ya fue descrita en otras situaciones debilitantes como el alcoholismo, desnutrición, diabetes etc. Eventualmente puede verse en pacientes inmunocompetentes como los 2 casos que presentamos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Syphilis is a multifaceted disease that always requires differential diagnoses. A rare form of secondary syphilis is the so-called malignant syphilis characterized by necrotic ulcerated lesions covered by thick crusts with a rupioid or ostraceous appearance. Currently observed mainly in patients infected with the human immunodeficiency virus, but it was previously described in other debilitating situations such as alcoholism, y malnutrition. Eventually it can be seen in immunocompetent patients like the 2 cases we present.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[sífilis]]></kwd>
<kwd lng="es"><![CDATA[sífilis maligna]]></kwd>
<kwd lng="es"><![CDATA[diagnóstico de sífilis.]]></kwd>
<kwd lng="en"><![CDATA[syphilis]]></kwd>
<kwd lng="en"><![CDATA[malignant syphilis]]></kwd>
<kwd lng="en"><![CDATA[diagnosis of syphilis.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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