1816-8949 1816-8949 S1816-89492022000300138 10.18004/anales/2022.055.03.138 Paraguay Paraguay Paraguay 00 12 2022 00 12 2022 55 3 138 139 1 2020 11 4 4 2 2020 1-24 3 2017 26 9 9 1067-79 4 2019 7 1 1 10 5 2020 11 5 5 1172-87