1816-8949 1816-8949 S1816-89492022000300043 10.18004/anales/2022.055.03.43 Paraguay Paraguay 00 12 2022 00 12 2022 55 3 43 50

1 2012 7 1 1 2 2019 92 6-10 3 2002 Vol. 25 109-15 4 WHO 2000 5 Organización Mundial de la Salud 2021 6 2022 10 26 26 147-75 7 2022 137 7 7 972-81 8 National Institutes of Health Consensus Conference 1991 115 956-61 9 1978 10 2011 96 3067-77 11 2020 6 1 1 45-52 12 2021 73 6 6 763-70 13 2012 6 1 1 7 14 2012 7 1 1 15 National Institutes of Health 1985 5 1-7 16 2013 9 6 6 914-9 17 2014 10 6 6 1226-32 18 2022 28 1 1 2-11 19 2022 37 2 2 259-79 20 2022 39 2 2 305-12 21 2022 16 2 2 25-34 22 2022 14 1 1 42-7