<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1816-8949</journal-id>
<journal-title><![CDATA[Anales de la Facultad de Ciencias Médicas (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[An. Fac. Cienc. Méd. (Asunción)]]></abbrev-journal-title>
<issn>1816-8949</issn>
<publisher>
<publisher-name><![CDATA[EFACIM. Editorial de la Facultad de Ciencias Médicas - Universidad Nacional de Asunción]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1816-89492019000200053</article-id>
<article-id pub-id-type="doi">10.18004/anales/2019.052(02)53-058</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Enfermedad de Bowen de localización inusual]]></article-title>
<article-title xml:lang="en"><![CDATA[Bowen's disease of unusual location]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilar Naville]]></surname>
<given-names><![CDATA[Silvia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Di Martino Ortiz]]></surname>
<given-names><![CDATA[Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Masi]]></surname>
<given-names><![CDATA[Mirtha]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bolla de Lezcano]]></surname>
<given-names><![CDATA[Lourdes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ávila]]></surname>
<given-names><![CDATA[María José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escobar Ortiz]]></surname>
<given-names><![CDATA[Evelyn]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Hospital de Clínicas, Cátedra de Dermatología]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Hospital de Clínicas, Departamento de Mastología]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>52</volume>
<numero>2</numero>
<fpage>53</fpage>
<lpage>58</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1816-89492019000200053&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1816-89492019000200053&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1816-89492019000200053&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La enfermedad de Bowen es un carcinoma de células escamosas intraepidérmico con potencial invasor que se ve con mayor frecuencia en mayores de 60 años. Se presenta usualmente como una placa eritematosa de crecimiento lento en zonas fotoexpuestas. Presentamos el caso de una mujer de 65 años con carcinoma escamoso in situ variedad pagetoide localizado en la mama izquierda en el cual fue determinante la inmunohistoquímica para realizar el diagnóstico final.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Bowen's disease is an intraepidermal squamous cell carcinoma with invasive potential that is seen more frequently in people older than 60 years. It usually occurs as a slow-growing erythematous plaque in photo-exposed areas. We present the case of a 65-year-old woman with squamous cell carcinoma in situ pagetoid variety located in the left breast, in which immunohistochemistry was decisive in order to make the final diagnosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[enfermedad de Bowen]]></kwd>
<kwd lng="es"><![CDATA[carcinoma escamoso in situ]]></kwd>
<kwd lng="es"><![CDATA[neoplasias pagetoides]]></kwd>
<kwd lng="es"><![CDATA[inmunohistoquímica.]]></kwd>
<kwd lng="en"><![CDATA[Bowen's disease]]></kwd>
<kwd lng="en"><![CDATA[squamous cell carcinoma in situ]]></kwd>
<kwd lng="en"><![CDATA[pagetoid neoplasms]]></kwd>
<kwd lng="en"><![CDATA[immunohistochemistry.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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