<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1816-8949</journal-id>
<journal-title><![CDATA[Anales de la Facultad de Ciencias Médicas (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[An. Fac. Cienc. Méd. (Asunción)]]></abbrev-journal-title>
<issn>1816-8949</issn>
<publisher>
<publisher-name><![CDATA[EFACIM. Editorial de la Facultad de Ciencias Médicas - Universidad Nacional de Asunción]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1816-89492019000100017</article-id>
<article-id pub-id-type="doi">10.18004/anales/2019.052(01)17-024</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Necrólisis cutánea - Casuística de 25 años]]></article-title>
<article-title xml:lang="en"><![CDATA[Cutaneous necrolysis - Casuistry of 25 years]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aldama Caballero]]></surname>
<given-names><![CDATA[Arnaldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aldama Negrete]]></surname>
<given-names><![CDATA[Fabián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Nacional Itauguá Servicio de Dermatología ]]></institution>
<addr-line><![CDATA[ Central]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>52</volume>
<numero>1</numero>
<fpage>17</fpage>
<lpage>24</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1816-89492019000100017&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1816-89492019000100017&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1816-89492019000100017&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La Necrólisis Epidérmica es una reacción grave y potencialmente mortal, inducida sobre todo por fármacos. Incluye 2 cuadros que presentan similitudes histológicas, etio-patogénicas, pero difieren en el porcentaje de piel afectada: el Síndrome de Stevens-Johnson y la Necrólisis Epidérmica Tóxica. Existen cuadros intermedios entre ambas entidades. El objetivo del trabajo es comunicar las características clínico-epidemiológicas de los casos de Necrólisis Epidérmica registrados en el Hospital Nacional en un periodo de 25 años.  Materiales y Métodos:  Estudio retrospectivo, descriptivo de los casos de Necrólisis Epidérmica en sus variantes Síndrome de Stevens-Johnson, Necrólisis Epidérmica Tóxica y cuadros intermedios registrados en el Servicio de Dermatología del Hospital Nacional en el periodo 1992-2017.  Resultados:  Se registraron 46 casos, 27 de Stevens-Johnson, 15 de Necrólisis Epidérmica Tóxica y 4 intermedios. Los casos se observaron en ambos sexos por igual, con edad media de 26.7años (DE 20,69). Los fármacos involucrados con más frecuencia fueron los antibióticos en 16 casos (penicilina y derivados en primer lugar), los anticonvulsivantes (13 casos) predominando la difenilhidantoina y antiinflamatorios-analgésicos (11 casos). El tratamiento consistió en medidas generales en todos, corticoides sistémico en 21 casos y gammaglobulina en 3. La mortalidad global fue del 28%, llegando al 46% en la Necrólisis Epidérmica Tóxica.  Conclusiones:  La Necrólisis Epidérmica es un cuadro poco frecuente pero grave, con elevada mortalidad, causado principalmente por antibióticos y anticonvulsivantes en esta serie, al igual que en la mayoría de otras series.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Epidermal Necrolysis is a serious and potentially fatal reaction, induced mainly by drugs. It includes 2 clinical pictures that present histological, etio-pathogenic similarities, but differ in the percentage of affected skin: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. There are intermediate tables between both entities. The objective of the work is to communicate features epidemiological cases of Epidermal Necrolysis reported at a National Hospital in a period of 25 years.  Materials and methods:  Retrospective, descriptive study of the cases of Epidermal Necrolysis in its variants Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis and intermediate tables registered in the Dermatology Service of the National Hospital in the period 1992-2017.  Results:  46 cases were registered, 27 of Stevens-Johnson, 15 of Toxic Epidermal Necrolysis and 4 intermediate. Cases were observed in both sexes equally, with an average age of 26.7 years (SD 20.69) The drugs most frequently involved were antibiotics in 16 cases (penicillin and derivatives in the first place), anticonvulsants (13 cases), predominantly diphenylhydantoin and anti-inflammatory-analgesics (11 cases). The treatment consisted of general measures in all, systemic corticoids in 21 cases and gamma globulin in 3. The overall mortality was 28%, reaching 46% in Toxic Epidermal Necrolysis.  Conclusions:  Epidermal necrolysis is a rare but serious condition, with high mortality, caused mainly by antibiotics and anticonvulsants in this series, as in most other series.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Necrólisis Epidérmica]]></kwd>
<kwd lng="es"><![CDATA[Síndrome de Stevens-Johnson]]></kwd>
<kwd lng="es"><![CDATA[Necrólisis Epidérmica Tóxica]]></kwd>
<kwd lng="es"><![CDATA[Reacción adversa a fármacos.]]></kwd>
<kwd lng="en"><![CDATA[Epidermal Necrolysis]]></kwd>
<kwd lng="en"><![CDATA[Stevens-Johnson Syndrome]]></kwd>
<kwd lng="en"><![CDATA[Toxic Epidermal Necrolysis]]></kwd>
<kwd lng="en"><![CDATA[Adverse Drug Reaction.]]></kwd>
</kwd-group>
</article-meta>
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