<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1812-9528</journal-id>
<journal-title><![CDATA[Memorias del Instituto de Investigaciones en Ciencias de la Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Mem. Inst. Investig. Cienc. Salud]]></abbrev-journal-title>
<issn>1812-9528</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Investigaciones en Ciencias de la Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1812-95282026000100203</article-id>
<article-id pub-id-type="doi">10.18004/mem.iics/1812-9528/2026.e24122603</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evolución clínica comparativa entre el manejo terapéutico médico conservador versus el tratamiento quirúrgico en pacientes con estenosis aórtica severa]]></article-title>
<article-title xml:lang="en"><![CDATA[Comparative clinical outcome between the conservative medical management versus the surgical treatment in patients with severe aortic stenosis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Canata]]></surname>
<given-names><![CDATA[Javier Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morán]]></surname>
<given-names><![CDATA[Alberto J]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chávez]]></surname>
<given-names><![CDATA[Christian O]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sequeira]]></surname>
<given-names><![CDATA[Orlando R]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Meza]]></surname>
<given-names><![CDATA[Alfredo Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Falcón]]></surname>
<given-names><![CDATA[Rocío del Pilar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[Laura B]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Scavenius]]></surname>
<given-names><![CDATA[Karina E]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torales]]></surname>
<given-names><![CDATA[Judith M]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Centurión]]></surname>
<given-names><![CDATA[Osmar A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Hospital de Clínicas ]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Sanatorio Metropolitano Departamento de Investigación en Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Fernando de la Mora ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<volume>24</volume>
<numero>1</numero>
<fpage>203</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1812-95282026000100203&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1812-95282026000100203&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1812-95282026000100203&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Según las guías de práctica clínica la sustitución valvular aórtica (SVAo) es el tratamiento de elección para la estenosis aórtica (EAo) severa sintomática. A pesar de las opciones actuales, muchos de los pacientes con EAo severa sintomática son manejados con farmacoterapia. Este registro retrospectivo incluyó a adultos con EAo severa (gradiente medio &#8805;40 mmHg o área valvular aórtica &lt;1 cm²). Las variables registradas incluyeron parámetros clínicos y ecocardiográficos, índice de comorbilidad de Charlson y EuroSCORE II. Se revisó la supervivencia de los pacientes y la intervención de la válvula aórtica. Se incluyeron un total de 64 pacientes, con edad media de 66,83±14,30, de los cuales 40 (62,50%) eran hombres y 24 (37,50%) eran mujeres. El manejo terapéutico más frecuente fue el tratamiento conservador en 38 pacientes (59,38%), y el tratamiento quirúrgico fue realizado en 26 pacientes (40,62%). De los 22 pacientes fallecidos, 17 tuvieron tratamiento conservador (77,27%) y 5 quirúrgico (22,73%), de los cuales los días de sobrevivencia post-intervención tuvo una media de 261,67±521,68 días para las causas de muerte no cardiaca y de 1183,5 ± 52,5 días para las causas cardiacas. La mayoría de los pacientes con EAo severa fueron tratados de forma conservadora. Las dos principales razones para elegir esta opción fueron la decisión del paciente y la presencia de comorbilidades. Los predictores independientes de mortalidad fueron la comorbilidad objetivada por escala de Charlson (&gt;3), la FEVI deprimida, el riesgo quirúrgico (EuroSCORE II &gt; 5), el diagnóstico de EAo severa en pacientes hospitalizados y la insuficiencia renal.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Aortic stenosis (AS) is the most common heart valve disease in developed countries and has a poor prognosis when symptoms appear. According to clinical practice guidelines, aortic valve replacement (AVR) is the treatment of choice for severe symptomatic AS. Despite current options, many patients with severe symptomatic AS are managed with pharmacotherapy. A retrospective registry included all adults with severe AS (mean gradient &#8805;40 mmHg or aortic valve area &lt;1 cm²). Recorded variables included clinical and echocardiographic parameters, the Charlson comorbidity index, and EuroSCORE II. Patient survival and aortic valve intervention were reviewed. In cases treated conservatively, the main reasons for this decision were recorded. A total of 64 patients were included, with a mean age of 66.83 ± 14.30, of whom 40 (62.50%) were men and 24 (37.50%) were women. The most common therapeutic approach was conservative treatment in 38 patients (59.38%), and surgical treatment was performed in 26 patients (40.62%). Of the 22 patients who died, 17 received conservative treatment (77.27%) and 5 received surgery (22.73%). The mean post-intervention survival time was 261.67 ± 521.68 days for non-cardiac causes of death and 1183.5 ± 52.5 days for cardiac causes. Most patients with severe AS are treated conservatively. The two main reasons for choosing this option were patient choice and the presence of comorbidities. The independent predictors of mortality were comorbidity assessed by the Charlson score (&gt;3), reduced LVEF, surgical risk (EuroSCORE II &gt;5), diagnosis of severe AS in hospitalized patients, and renal failure.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Estenosis aórtica severa]]></kwd>
<kwd lng="es"><![CDATA[reemplazo valvular aórtico]]></kwd>
<kwd lng="es"><![CDATA[farmacoterapia]]></kwd>
<kwd lng="es"><![CDATA[mortalidad cardiaca]]></kwd>
<kwd lng="en"><![CDATA[Severe aortic stenosis]]></kwd>
<kwd lng="en"><![CDATA[aortic valve replacement]]></kwd>
<kwd lng="en"><![CDATA[cardiac mortality]]></kwd>
</kwd-group>
</article-meta>
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