<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1812-9528</journal-id>
<journal-title><![CDATA[Memorias del Instituto de Investigaciones en Ciencias de la Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Mem. Inst. Investig. Cienc. Salud]]></abbrev-journal-title>
<issn>1812-9528</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Investigaciones en Ciencias de la Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1812-95282022000300148</article-id>
<article-id pub-id-type="doi">10.18004/mem.iics/1812-9528/2022.020.03.148</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome combinado de fibrosis pulmonar y enfisema: albores del tratamiento antifibrótico en el Paraguay]]></article-title>
<article-title xml:lang="en"><![CDATA[Combined pulmonary fibrosis and emphysema syndrome: dawn of antifibrotic treatment in Paraguay]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Bejarano]]></surname>
<given-names><![CDATA[Domingo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General de Luque Servicio de Neumología Área Consultorio Externo]]></institution>
<addr-line><![CDATA[Luque ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>20</volume>
<numero>3</numero>
<fpage>148</fpage>
<lpage>154</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1812-95282022000300148&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1812-95282022000300148&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1812-95282022000300148&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La concomitancia de fibrosis pulmonar en regiones inferiores del pulmón y enfisema en lóbulos superiores caracterizan a una entidad poco frecuente denominada síndrome combinado de fibrosis pulmonar y enfisema, que usualmente se asocia a alta carga de tabaquismo, aunque se describen otras asociaciones y que conlleva un pronóstico sombrío. La hipertensión pulmonar, el cáncer de pulmón y la exacerbación aguda son complicaciones posibles. En el contexto de un enfoque multidisciplinar de manejo de tres casos, relatamos el curso del tratamiento con pirfenidona.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The concomitance of pulmonary fibrosis in the lower regions of the lung and emphysema in the upper lobes characterize a rare entity called combined pulmonary fibrosis and emphysema syndrome, which is usually associated with a high burden of smoking, although other associations have been described and which carries a poor prognosis. Pulmonary hypertension, lung cancer, and acute exacerbation are possible complications. In the context of a multidisciplinary approach to the management of three cases, we report the course of treatment with pirfenidone.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Combinación de fibrosis pulmonar y enfisema]]></kwd>
<kwd lng="es"><![CDATA[enfisema pulmonar]]></kwd>
<kwd lng="es"><![CDATA[fibrosis pulmonar]]></kwd>
<kwd lng="es"><![CDATA[tabaquismo]]></kwd>
<kwd lng="es"><![CDATA[hipertensión pulmonar]]></kwd>
<kwd lng="en"><![CDATA[Combination of pulmonary fibrosis and emphysema]]></kwd>
<kwd lng="en"><![CDATA[pulmonary emphysema]]></kwd>
<kwd lng="en"><![CDATA[pulmonary fibrosis]]></kwd>
<kwd lng="en"><![CDATA[smoking]]></kwd>
<kwd lng="en"><![CDATA[pulmonary hypertension]]></kwd>
</kwd-group>
</article-meta>
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