<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1812-9528</journal-id>
<journal-title><![CDATA[Memorias del Instituto de Investigaciones en Ciencias de la Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Mem. Inst. Investig. Cienc. Salud]]></abbrev-journal-title>
<issn>1812-9528</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Investigaciones en Ciencias de la Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1812-95282019000200024</article-id>
<article-id pub-id-type="doi">10.18004/mem.iics/1812-9528/2019.017.02.24-035</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Concentración de fluoruro en agua subterránea y su relación con los niveles de calcio sérico en niños residentes en el distrito de Loreto, Concepción, Paraguay]]></article-title>
<article-title xml:lang="en"><![CDATA[Fluoride concentration in groundwater and its relationship with serum calcium levels in children living in Loreto, Concepción, Paraguay]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Diez Pérez]]></surname>
<given-names><![CDATA[Diana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[Marcelo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Colmán]]></surname>
<given-names><![CDATA[Derlysa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[Cecilia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Navarro]]></surname>
<given-names><![CDATA[Nathalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morínigo]]></surname>
<given-names><![CDATA[Macarena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Araujo]]></surname>
<given-names><![CDATA[Silvia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cáceres]]></surname>
<given-names><![CDATA[Annelice]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pizzurno]]></surname>
<given-names><![CDATA[Johana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yubero]]></surname>
<given-names><![CDATA[Fátima]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Químicas Departamento de Fisicoquímica, Dirección de Investigaciones]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Químicas Departamento de Bioquímica Clínica, Dirección de Investigaciones]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Químicas Departamento de Nutrición, Dirección de Investigaciones]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>17</volume>
<numero>2</numero>
<fpage>24</fpage>
<lpage>35</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1812-95282019000200024&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1812-95282019000200024&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1812-95282019000200024&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Como parte del ciclo biogeoquímico, el fluoruro del suelo puede disolverse e ingresar al agua. La Organización Mundial de la Salud y la Norma Paraguaya NP 24 001 80 establecen una concentración máxima de 1,5 mg.L-1 de fluoruro en agua de consumo, pudiendo producir fluorosis cuando es elevada, tal como se encontró en niños residentes de Loreto. Estudios indican que la exposición al fluoruro concomitante al déficit de calcio puede agravar la pérdida de masa ósea, causando fragilidad y fluorosis esquelética. Además, se demostró mediante bioensayos en ratones que el exceso de fluoruro reduce la concentración de calcio sérico, por lo que el objetivo del estudio descriptivo con componente analítico fue elaborar un mapa de distribución espacial de fluoruro del agua subterránea de Loreto y relacionar con la calcemia en niños. Se determinó la concentración de fluoruro en muestras de veintitrés pozos de agua subterránea y el calcio sérico de dieciocho niños en edad escolar, ambos por método normalizado. Se identificaron dos pozos con concentraciones superiores al máximo permitido y en 61% de los niños el calcio sérico fue inferior al valor de referencia. Se encontró una correlación débil entre las variables (r = 0,212). El estudio proporciona información relevante sobre sitios con elevadas concentraciones de fluoruro lo que representa un riesgo para la salud pues aun con ingesta adecuada de calcio, los niños presentaron hipocalcemia. Sería importante incluir en estudios posteriores factores no abordados en esta investigación para una evaluación más completa del riesgo de la población expuesta.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT As part of the biogeochemical cycle, soil fluoride can dissolve and accumulate in groundwater. World Health Organization and the Paraguayan Standard NP 24 001 80 establishes of 1.5 mg.L-1 of fluoride in drinking water, which can produce fluorosis when it is higher, as it has been found in children of Loreto. Studies indicate that exposure to fluoride concomitant with calcium deficit may aggravate bone loss, causing frailty and skeletal fluorosis. In addition, it was demonstrated through bioassays in mice that excess fluoride reduces serum calcium concentration, the objective of the descriptive study with the analytical component has become a spatial distribution map of Loreto groundwater and related to calcemia in children. The fluoride concentration was determined in samples from twenty-three groundwater wells and serum calcium from eighteen school-age children, both by standard method. Two points were identified with levels above the maximum allowed and in 61% of the children the serum calcium was lower than the reference value. We found a weak correlation between the variables (r = 0.212). It would be important to include in later studies factors not addressed in this research for a more complete risk assessment of the exposed population.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[fluoruro]]></kwd>
<kwd lng="es"><![CDATA[calcio sérico]]></kwd>
<kwd lng="es"><![CDATA[distribución espacial]]></kwd>
<kwd lng="en"><![CDATA[fluoride]]></kwd>
<kwd lng="en"><![CDATA[seric calcium]]></kwd>
<kwd lng="en"><![CDATA[spacial distribution]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Avila]]></surname>
<given-names><![CDATA[NM]]></given-names>
</name>
<name>
<surname><![CDATA[Farias]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Bianco]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Bovi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mitre]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Determinación de fluoruro en aguas de Rinconadillas (Provincia de Jujuy)]]></article-title>
<source><![CDATA[Acta Toxicol. Argent.]]></source>
<year>2008</year>
<volume>16</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>14-20</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Godoy]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Aplicación de medios filtrantes para reducción de fluoruros en agua para consumo. Disertación (maestría)]]></source>
<year>2003</year>
<page-range>128</page-range><publisher-loc><![CDATA[Guatemala ]]></publisher-loc>
<publisher-name><![CDATA[Universidad San Carlos]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lupo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Lombarte]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Fina]]></surname>
<given-names><![CDATA[BL]]></given-names>
</name>
<name>
<surname><![CDATA[Rigalli]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Development of a household method for treatment of highly fluoridated water using processed eggshell]]></article-title>
<source><![CDATA[Actual. Osteol.]]></source>
<year>2015</year>
<volume>11</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>209-19</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huízar Álvarez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Carrillo Rivera]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Juárez]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fluoruro en el agua subterránea: niveles, origen y control natural en la región de Tenextepango, Morelos, México]]></article-title>
<source><![CDATA[Invest. Geog.]]></source>
<year>2016</year>
<volume>90</volume>
<page-range>40-58</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marimon]]></surname>
<given-names><![CDATA[MP]]></given-names>
</name>
<name>
<surname><![CDATA[Roisenberg]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Suhogusoff]]></surname>
<given-names><![CDATA[AV]]></given-names>
</name>
<name>
<surname><![CDATA[Viero]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hydrogeochemistry and statistical analysis applied to understand fluoride provenance in the Guarani aquifer system, southern Brazil]]></article-title>
<source><![CDATA[Environmental Geochemistry And Health]]></source>
<year>2013</year>
<volume>35</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>391-403</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Olaka]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Wilke]]></surname>
<given-names><![CDATA[FD]]></given-names>
</name>
<name>
<surname><![CDATA[Olago]]></surname>
<given-names><![CDATA[DO]]></given-names>
</name>
<name>
<surname><![CDATA[Odada]]></surname>
<given-names><![CDATA[EO]]></given-names>
</name>
<name>
<surname><![CDATA[Mulch]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Musolff]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Groundwater fluoride enrichment in an active rift setting: Central Kenya Rift case study]]></article-title>
<source><![CDATA[Science Of The Total Environment]]></source>
<year>2016</year>
<volume>545</volume>
<page-range>641-53</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jones]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Burt]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Petersen]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Lennon]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The effective use of fluorides in public health]]></article-title>
<source><![CDATA[Bulletin of the World Health Organization]]></source>
<year>2005</year>
<volume>83</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>670-6</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arnold]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Dean]]></surname>
<given-names><![CDATA[HT]]></given-names>
</name>
<name>
<surname><![CDATA[Knutson]]></surname>
<given-names><![CDATA[JW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of fluoridated public water supplies on dental caries prevalence. Results of the seventh year of study at Grand Rapids and Muskegon, Michigan]]></article-title>
<source><![CDATA[Public Health Reports]]></source>
<year>1953</year>
<volume>68</volume>
<page-range>141-8</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="">
<collab>Instituto Nacional de Tecnología, Normalización y Metrología</collab>
<source><![CDATA[Norma Paraguaya NP 24 001 80 &#8220;Agua Potable&#8221;]]></source>
<year>2011</year>
<edition>6°</edition>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rosal]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Eliminación de fluoruros en agua potable]]></source>
<year>2007</year>
<publisher-name><![CDATA[Red Madrileña de Tratamientos Avanzados para Aguas Residuales con Contaminantes no Biodegradables]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<collab>U.S. Department of Health and Human Services Federal Panel on Community Water Fluoridation</collab>
<article-title xml:lang=""><![CDATA[Public Health Service Recommendation for Fluoride Concentration in Drinking Water for the Prevention of Dental Caries]]></article-title>
<source><![CDATA[Public Health Reports]]></source>
<year>2015</year>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aguilera]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Domínguez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Acevedo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rojas]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Niveles de fluoruro en alimentos de la cesta básica en el estado Aragua]]></article-title>
<source><![CDATA[Acta odontol. venez]]></source>
<year>2006</year>
<volume>44</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>87-95</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Garaulet]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gil]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Zamora-Navarro]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Calcio, fósforo, magnesio y flúor. Metabolismo óseo y su regulación]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Gil Hernández]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Tratado de nutrición]]></source>
<year>2005</year>
<page-range>897-926</page-range><publisher-loc><![CDATA[Madrid ]]></publisher-loc>
<publisher-name><![CDATA[Acción Médica]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kubota]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Tsuchiva]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Young]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Everett]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez-Mier]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fluoride Induces Endoplasmic Reticulum Stress in Ameloblasts Responsible for Dental Enamel Formation]]></article-title>
<source><![CDATA[The Journal Of Biological Chemistry]]></source>
<year>2005</year>
<volume>280</volume>
<numero>24</numero>
<issue>24</issue>
<page-range>23194-202</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zaror]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Vallejos]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Corsini]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[De La Puente]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Velásquez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Tessada-Sepúlvedar]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Revisión sistemática sobre los efectos adversos de la fluoración del agua]]></article-title>
<source><![CDATA[Int. J. Odontostomat.]]></source>
<year>2015</year>
<volume>9</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>165-71</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ba]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serum calciotropic hormone levels, and dental fluorisis in children exposed to different concentrations of fluoride and iodine in drinking water]]></article-title>
<source><![CDATA[Chin Med J (Beijing)]]></source>
<year>2010</year>
<volume>123</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>675-9</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fo&#269;ak]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Haskovi&#263;]]></surname>
<given-names><![CDATA[EB]]></given-names>
</name>
<name>
<surname><![CDATA[Suljevi&#263;]]></surname>
<given-names><![CDATA[DB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The effect of fluoride on the serum level of calcium in the rat (Rattus norvegicus)]]></article-title>
<source><![CDATA[Archives Of Biological Sciences (Serbia)]]></source>
<year>2012</year>
<numero>4</numero>
<issue>4</issue>
<page-range>1585</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Simon]]></surname>
<given-names><![CDATA[MJK]]></given-names>
</name>
<name>
<surname><![CDATA[Beil]]></surname>
<given-names><![CDATA[FT]]></given-names>
</name>
<name>
<surname><![CDATA[Rüther]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Busse]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Koehne]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Steiner]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[High fluoride and low calcium levels in drinking water is associated with low bone mass, reduced bone quality and fragility fractures in sheep]]></article-title>
<source><![CDATA[Osteoporos Int.]]></source>
<year>2014</year>
<volume>25</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>1891-903</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Rubio]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Gutiérrez]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[GL]]></given-names>
</name>
<name>
<surname><![CDATA[de la Torre]]></surname>
<given-names><![CDATA[AH]]></given-names>
</name>
<name>
<surname><![CDATA[Revert]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[El agua de consumo como fuente de exposición crónica a fluoruro en Tenerife; evaluación del riesgo]]></article-title>
<source><![CDATA[Nutr Hosp.]]></source>
<year>2015</year>
<volume>31</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1787-94</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ayoob]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gupta]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fluoride in Drinking Water: A Review on the Status and Stress Effects. Critical Reviews]]></article-title>
<source><![CDATA[Environmental Science &amp; Technology]]></source>
<year>2006</year>
<volume>36</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>433-87</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Núñez]]></surname>
<given-names><![CDATA[HA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fluorosis dental en niños de localidades del Paraguay con elevado tenor de flúor en las aguas de consumo humano]]></article-title>
<source><![CDATA[Mem Inst Investig Cienc Salud]]></source>
<year>2011</year>
<volume>7</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>35-42</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Insaurralde]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Municipalidad de Loreto: &#8220;Tierra donde fluye la miel y reina el guavirami&#8221;]]></source>
<year>2010</year>
<page-range>1-16</page-range><publisher-loc><![CDATA[Loreto ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="book">
<collab>APHA/AWWA/WEF</collab>
<source><![CDATA[Standard Methods for examinations of water and wastewater]]></source>
<year>1992</year>
<edition>17</edition>
<page-range>4-102</page-range><publisher-loc><![CDATA[Washington ]]></publisher-loc>
<publisher-name><![CDATA[American Public Health Association]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="book">
<collab>U.S. Department of Agriculture and U.S. Department of Health and Human Services (USDA/HHS)</collab>
<source><![CDATA[Scientific report of the 2010 dietary guidelines advisory committee: advisory report to the secretary of health and human services and secretary of agriculture]]></source>
<year>2010</year>
<publisher-loc><![CDATA[Washington ]]></publisher-loc>
<publisher-name><![CDATA[USDA, Agricultural Research Service]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sanz]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<source><![CDATA[Química. Equilibrios químicos. Teoría, ejercicios resueltos y prácticas]]></source>
<year>2014</year>
<page-range>14-54</page-range><publisher-loc><![CDATA[España ]]></publisher-loc>
<publisher-name><![CDATA[Vision libros]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[de Llamas]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Molinas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Franco]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estudio de reconocimiento de suelos. Capacidad de uso de tierra y propuesta de ordenamiento territorial preliminar de la región oriental del Paraguay]]></article-title>
<source><![CDATA[Ministerio de Agricultura y Ganadería]]></source>
<year>1995</year>
<volume>I</volume>
</nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gago]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Romar]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez-Marcos]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Álvarez]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fluoride sorption and desorption on soils located in the surroundings of an aluminium smelter in Galicia]]></article-title>
<source><![CDATA[Environ Earth Sci]]></source>
<year>2014</year>
<volume>72</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>4105-14</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chakraborty]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pandey]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pandey]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Spectrophotometric method vs ion selective electrode for field determination of fluoride in water and complex samples]]></article-title>
<source><![CDATA[Reserch J Chem Sci]]></source>
<year>2017</year>
<volume>7</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>31-7</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="">
<collab>USEPA</collab>
<source><![CDATA[Integrated Risk Information System]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wen]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cui]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Guo]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Relationship of PTH Bst BI Polymorphism, Calciotropic Hormone Levels, and Dental Fluorosis of Children in China]]></article-title>
<source><![CDATA[Biol Trace Elem Res]]></source>
<year>2012</year>
<volume>147</volume>
<numero>1-3</numero>
<issue>1-3</issue>
<page-range>84-90</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ryczel]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fluor y agua de consume - Su relación con la salud - Controversias sobre la necesidad de fluorar el agua de consumo]]></article-title>
<source><![CDATA[Boletín de la Asociación Toxicológica Argentina]]></source>
<year>2006</year>
<volume>20</volume>
<numero>72</numero>
<issue>72</issue>
<page-range>21-6</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Levine]]></surname>
<given-names><![CDATA[BS]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Felsenfeld]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serum calcium and bone: effect of PTH, phosphate, vitamin D and uremia]]></article-title>
<source><![CDATA[Nefrologia]]></source>
<year>2014</year>
<volume>34</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>658-69</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cámara-Martos]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Amaro-López]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Influence of Dietary Factors on Calcium Bioavailability A Brief Review]]></article-title>
<source><![CDATA[Biological Trace Element Research]]></source>
<year>2002</year>
<volume>89</volume>
<page-range>1-10</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
