<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1683-9803</journal-id>
<journal-title><![CDATA[Pediatría (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[Pediatr. (Asunción)]]></abbrev-journal-title>
<issn>1683-9803</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Pediatría]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1683-98032021000200127</article-id>
<article-id pub-id-type="doi">10.31698/ped.48022021007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización clínica y laboratorial de pacientes pediátricos con dengue sin signos de alarma en un hospital de referencia de Paraguay]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical and laboratory characterization of pediatric patients with dengue without warning signs in a reference hospital in Paraguay]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bernal Vega]]></surname>
<given-names><![CDATA[Erica Eliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Iramain Chilavert]]></surname>
<given-names><![CDATA[Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jara Ávalos]]></surname>
<given-names><![CDATA[Alfredo Ramón]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Delvalle Acosta]]></surname>
<given-names><![CDATA[Edith María Rossana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arzamendia Alarcón]]></surname>
<given-names><![CDATA[Laura Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Román Almada]]></surname>
<given-names><![CDATA[Landhy Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Hospital de Clínicas]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<volume>48</volume>
<numero>2</numero>
<fpage>127</fpage>
<lpage>132</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1683-98032021000200127&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1683-98032021000200127&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1683-98032021000200127&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: El virus del Dengue es transmitido por la picadura de mosquitos hembra de Aedes aegypti. En Paraguay constituye una enfermedad endémica, con epidemias cada 3-5 años, y con diferentes tipos de presentación, desde formas asintomáticas hasta formas graves, que incluso puede desencadenar la muerte.  Objetivo:  Describir las características clínicas y laboratoriales de pacientes en edad pediátrica con diagnóstico de Dengue sin signos de alarma que acudieron al consultorio del Departamento de Urgencias Pediátricas del Hospital de Clínicas de San Lorenzo, Paraguay, entre noviembre de 2019 y marzo de 2020.  Materiales y Métodos:  Estudio descriptivo, observacional, retrospectivo, de corte transverso de casos consecutivos. Se incluyeron pacientes de 1 mes a 18 años en un muestreo no probabilístico.  Resultados:  Se incluyeron 221 pacientes. Se obtuvo una edad promedio de 8,6 años, siendo el 51% de sexo femenino. En cuanto a la sintomatología, el 100% de los pacientes manifestaron la presencia de fiebre, seguido en frecuencia por cefalea (45%), dolor corporal (36%) y vómitos (18%). Se realizó análisis de detección de antígeno NS1 en 107 pacientes, de los cuales 75 resultaron positivos.  Conclusión: Se observó una distribución similar en cuanto al sexo, con una mediana de edad de 8 años. Las manifestaciones clínicas más frecuentes fueron fiebre, cefalea y dolor corporal, sin embargo, se registró una mayor frecuencia de pacientes con síntomas gastrointestinales respecto a brotes de años anteriores, probablemente relacionado con el serotipo circulante. Se obtuvo un 70% de positividad de la prueba de antígeno NS1.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Dengue virus is transmitted by the bite of female Aedes aegypti mosquitoes. In Paraguay it is an endemic disease, with epidemics every 3-5 years, and with different types of presentation, from asymptomatic to severe forms, which can even trigger death.  Objective: To describe the clinical and laboratory characteristics of pediatric patients with a diagnosis of Dengue without warning signs who presented to the Pediatric Emergency Department of the Hospital de Clínicas of San Lorenzo, Paraguay, between November 2019 and March 2020.  Materials and Methods: this was a descriptive, observational, retrospective, cross-sectional study of consecutive cases. Patients from 1 month to 18 years of age were included in a non-probability sampling.  Results:  221 patients were included. An average age of 8.6 years was obtained, with 51% being female. Regarding the symptoms, 100% of the patients manifested the presence of fever, followed in frequency by headache (45%), body pain (36%) and vomiting (18%). NS1 antigen detection analysis was performed in 107 patients, of which 75 were positive.  Conclusion:  A similar gender distribution was observed, with a median age of 8 years. The most frequent clinical manifestations were fever, headache, and body pain; however, a higher frequency of patients with gastrointestinal symptoms was recorded compared to outbreaks in previous years, probably related to the circulating serotype. The NS1 antigen test was 70% positive.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Fiebre dengue]]></kwd>
<kwd lng="es"><![CDATA[epidemiología]]></kwd>
<kwd lng="es"><![CDATA[Paraguay]]></kwd>
<kwd lng="en"><![CDATA[Dengue fever]]></kwd>
<kwd lng="en"><![CDATA[epidemiology]]></kwd>
<kwd lng="en"><![CDATA[Paraguay]]></kwd>
</kwd-group>
</article-meta>
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