<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1683-9803</journal-id>
<journal-title><![CDATA[Pediatría (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[Pediatr. (Asunción)]]></abbrev-journal-title>
<issn>1683-9803</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Pediatría]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1683-98032021000100044</article-id>
<article-id pub-id-type="doi">10.31698/ped.48012021008</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización clínica, epidemiológica y genética de pacientes con atrofia muscular espinal: serie de 26 pacientes pediátricos]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical, epidemiological and genetic characterization of patients with spinal muscular atrophy: a series of 26 pediatric patients]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Franco Toñánez]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Godoy Sánchez]]></surname>
<given-names><![CDATA[Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Casartelli Galeano]]></surname>
<given-names><![CDATA[Marco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Pediátrico Niños de Acosta Ñu  ]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2021</year>
</pub-date>
<volume>48</volume>
<numero>1</numero>
<fpage>44</fpage>
<lpage>50</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1683-98032021000100044&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1683-98032021000100044&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1683-98032021000100044&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La Atrofia Muscular Espinal 5q (AME 5q) es la forma más frecuente de atrofia muscular espinal y está relacionada con la mutación del gen SMN1. Se clasifica en 4 tipos según la edad de presentación y el máximo logro motor alcanzado.  Objetivo:  Describir las características clínicas, epidemiológicas y genéticas de pacientes pediátricos con AME 5q evaluados en el servicio de Neurología del Hospital General Pediátrico Niños de Acosta Ñu.  Materiales y Métodos:  Estudio observacional, descriptivo, retrospectivo, transversal. Fueron incluidos pacientes con diagnóstico de AME del Servicio de Neurología del Hospital General Pediátrico Niños de Acosta Ñu, desde julio 2013 a julio 2017. Variables: datos demográficos, síntomas, clasificación, estudio genético, complicaciones y evolución. Se utilizó estadística descriptiva. El comité de ética de investigación liberó el consentimiento informado.  Resultados:  Se incluyeron 26 pacientes con diagnóstico de AME 5q. El 57,5%(15/26) fueron del sexo masculino. Consultaron por: no camina (19,2%), dificultad respiratoria y escaso movimiento (19,2%). Tipos de AME 5q: I 15/26 (57,7%), II 8/26 (30,7%) y III 3/26 (11,5%). Mediana de edad de diagnóstico clínico y genético: 6 meses y 7,5 meses respectivamente. La alteración genética fue delección homocigota en exones 7 y 8 del gen SMN1. Complicaciones más frecuentes: respiratorias, nutricionales y osteoarticulares. Casi todos recibieron fisioterapia motora y respiratoria más soporte nutricional. Ninguno recibió tratamiento específico modificador. Fallecieron 12/15 de AME tipo I. La mediana de edad de fallecimiento fue 8 meses.  Conclusión:  se encontró un patrón clínico, epidemiológico y genético clásico, con diagnóstico clínico y genético tardíos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Spinal Muscular Atrophy 5q (SMA 5q) is the most frequent form of spinal muscular atrophy and is related to the mutation of the SMN1 gene. It is classified into 4 types according to the age of presentation and the maximum motor achievement achieved.  Objective:  To describe the clinical, epidemiological and genetic characteristics of pediatric patients with SMA 5q evaluated in the Neurology service of the Children&#8217;s General Hospital &#8220;Niños de Acosta Ñu&#8221;.  Materials and Methods:  This was an observational, descriptive, retrospective and cross-sectional study. Patients with a diagnosis of SMA from the Neurology Service of the Children&#8217;s General &#8220;Niños de Acosta Ñu&#8221;, from July 2013 to July 2017, were included. Variables: demographic data, symptoms, classification, genetic study, complications and evolution. Descriptive statistics were used. The research ethics committee determined informed consent was not required.  Results:  26 patients with a diagnosis of SMA 5q were included. 57.5% (15/26) were male. They consulted for: not walking (19.2%), respiratory distress and poor movement (19.2%). Types of SMA 5q: I 15/26 (57.7%), II 8/26 (30.7%) and III 3/26 (11.5%). Median age of clinical and genetic diagnosis: 6 months and 7.5 months respectively. The genetic alteration was homozygous deletion in exons 7 and 8 of the SMN1 gene. Most frequent complications: respiratory, nutritional and osteoarticular. Almost all received respiratory and motor physiotherapy plus nutritional support. None received specific modifying treatment. 12/15 of SMA type I died. The median age of death was 8 months.  Conclusion:  a classic clinical, epidemiological and genetic pattern was found, with late clinical and genetic diagnosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Atrofia muscular espinal]]></kwd>
<kwd lng="es"><![CDATA[niños]]></kwd>
<kwd lng="es"><![CDATA[epidemiología]]></kwd>
<kwd lng="es"><![CDATA[clínica]]></kwd>
<kwd lng="en"><![CDATA[Spinal muscular atrophy]]></kwd>
<kwd lng="en"><![CDATA[children]]></kwd>
<kwd lng="en"><![CDATA[epidemiology]]></kwd>
<kwd lng="en"><![CDATA[clinical]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mercuri]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Bertini]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Iannaccone]]></surname>
<given-names><![CDATA[ST]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Childhood spinal muscular atrophy controversies and challenges]]></article-title>
<source><![CDATA[Lancet Neurol]]></source>
<year>2012</year>
<volume>11</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>443-52</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ogino]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Wilson]]></surname>
<given-names><![CDATA[RB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Atrofia muscular espinal genética molecular y diagnóstico]]></article-title>
<source><![CDATA[Experto Rev Mol Diagn]]></source>
<year>2004</year>
<volume>4</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>15-29</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sugarman]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<name>
<surname><![CDATA[Nagan]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Akmaev]]></surname>
<given-names><![CDATA[VR]]></given-names>
</name>
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Rohlfs]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Detección de portadores panétnicos y diagnóstico prenatal de atrofia muscular espinal análisis de laboratorio clínico de&amp;gt; 72.400 muestras]]></article-title>
<source><![CDATA[Eur J Hum Genet]]></source>
<year>2012</year>
<volume>20</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>27-32</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="book">
<source><![CDATA[Grupo de trabajo de la Guía de Atención Pediátrica.Manejo de la Atrofia Muscular Infantil]]></source>
<year>2019</year>
<publisher-loc><![CDATA[Garrahan ]]></publisher-loc>
<publisher-name><![CDATA[Unidad Evaluación de Tecnología Sanitaria]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Darras]]></surname>
<given-names><![CDATA[BT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Spinal muscular atrophies]]></article-title>
<source><![CDATA[Pediatr Clin North Am]]></source>
<year>2015</year>
<volume>62</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>743-66</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Urrutia-Osorio]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz-García]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Perfil demográfico y clínico de pacientes con atrofia muscular espinal serie de 31 pacientes]]></article-title>
<source><![CDATA[Acta Pediatr Mex]]></source>
<year>2020</year>
<volume>41</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>47-57</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vilchis]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Najera]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez-Duran]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Najera]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Gonzalez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Refugio Rivera]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The high frequency of genetic diseases in hypotonic infants referred by neuropediatrics]]></article-title>
<source><![CDATA[Am J Med Genet A]]></source>
<year>2014</year>
<volume>164A</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>1702-5</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mesfin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Sponseller]]></surname>
<given-names><![CDATA[PD]]></given-names>
</name>
<name>
<surname><![CDATA[Leet]]></surname>
<given-names><![CDATA[AI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Spinal muscular atrophy manifestations and management]]></article-title>
<source><![CDATA[J Am Acad Orthop Surg]]></source>
<year>2012</year>
<volume>20</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>393-401</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bertoli]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Amicis]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Mastella]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Pieri]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Giaquinto]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Battezzati]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Spinal Muscular Atrophy, types I and II What are the differences in body composition and resting energy expenditure?]]></article-title>
<source><![CDATA[Clin Nutr]]></source>
<year>2017</year>
<volume>36</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1674-80</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tizzano]]></surname>
<given-names><![CDATA[EF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[La atrofia muscular espinal en el nuevo escenario terapéutico]]></article-title>
<source><![CDATA[Rev médica Clín Las Condes]]></source>
<year>2018</year>
<volume>29</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>512-20</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Messina]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[New Directions for SMA Therapy]]></article-title>
<source><![CDATA[J Clin Med]]></source>
<year>2018</year>
<volume>7</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>251</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castiglioni]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Levicán]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Rodillo]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Garmendia]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Pizarro]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Atrofia muscular espinal: Caracterización clínica, electrofisiológica y molecular de 26 pacientes]]></article-title>
<source><![CDATA[Rev. méd. Chile.]]></source>
<year>2011</year>
<volume>139</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>197-204</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Madrid Rodríguez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez Martínez]]></surname>
<given-names><![CDATA[PL]]></given-names>
</name>
<name>
<surname><![CDATA[Ramos Fernández]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Urda Cardona]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez Antón]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Atrofia muscular espinal revisión de nuestra casuística en los últimos 25 años]]></article-title>
<source><![CDATA[Un pediatra (Barc)]]></source>
<year>2015</year>
<volume>82</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>159-65</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Viñas]]></surname>
<given-names><![CDATA[PC]]></given-names>
</name>
<name>
<surname><![CDATA[Martín]]></surname>
<given-names><![CDATA[HI]]></given-names>
</name>
<name>
<surname><![CDATA[Zaldivar]]></surname>
<given-names><![CDATA[VT]]></given-names>
</name>
<name>
<surname><![CDATA[Garófalo]]></surname>
<given-names><![CDATA[GN]]></given-names>
</name>
<name>
<surname><![CDATA[Zayas]]></surname>
<given-names><![CDATA[GM]]></given-names>
</name>
<name>
<surname><![CDATA[Guerra]]></surname>
<given-names><![CDATA[BR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Análisis genético molecular en Atrofia Muscular Espinal]]></article-title>
<source><![CDATA[Rev Chil Pediatr]]></source>
<year>2013</year>
<volume>84</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>499-504</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ashrafzadeh]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Sadr-Nabavi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Asadian]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Akhondian]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Beiraghi Toosi]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Atrofia muscular espinal: un breve artículo de revisión]]></article-title>
<source><![CDATA[Revista Internacional de Pediatría]]></source>
<year>2014</year>
<volume>2</volume>
<numero>3.1</numero>
<issue>3.1</issue>
<page-range>211-5</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arnold]]></surname>
<given-names><![CDATA[WD]]></given-names>
</name>
<name>
<surname><![CDATA[Kassar]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Kissel]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Spinal muscular atrophy diagnosis and management in a new therapeutic era]]></article-title>
<source><![CDATA[Muscle Nerve]]></source>
<year>2015</year>
<volume>51</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>157-67</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nicole]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Diaz]]></surname>
<given-names><![CDATA[CC]]></given-names>
</name>
<name>
<surname><![CDATA[Frugier]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Melki]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Spinal muscular atrophy recent advances and future prospects]]></article-title>
<source><![CDATA[Muscle Nerve]]></source>
<year>2002</year>
<volume>26</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>4-13</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Valencia]]></surname>
<given-names><![CDATA[HD]]></given-names>
</name>
<name>
<surname><![CDATA[Rendón Muñoz]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Pineda]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Ortiz]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Montoya]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Cornejo]]></surname>
<given-names><![CDATA[JW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Características clínicas de los pacientes menores de 18 años con atrofia muscular espinal en Medellín, 2008 - 2013]]></article-title>
<source><![CDATA[Acta Neurol Colomb]]></source>
<year>2016</year>
<volume>32</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>9-17</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mercuri]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Finkel]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
<name>
<surname><![CDATA[Muntoni]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Wirth]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Montes]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Main]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diagnosis and management of spinal muscular atrophy Part 1: Recommendations for diagnosis, rehabilitation, orthopedic and nutritional care]]></article-title>
<source><![CDATA[Neuromuscul Disord]]></source>
<year>2018</year>
<volume>28</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>103-15</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Finkel]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
<name>
<surname><![CDATA[Mercuri]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Meyer]]></surname>
<given-names><![CDATA[OH]]></given-names>
</name>
<name>
<surname><![CDATA[Simonds]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
<name>
<surname><![CDATA[Schroth]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
<name>
<surname><![CDATA[Graham]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diagnosis and management of spinal muscular atrophy Part 2: Pulmonary and acute care; medications, supplements and immunizations; other organ systems; and ethics]]></article-title>
<source><![CDATA[Neuromuscul Disord]]></source>
<year>2018</year>
<volume>28</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>197-207</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
