Abstract

MONTIEL, Dora et al. Clinical and laboratory characteristics and mortality predictors of patients with COVID-19 admitted to the Hospital Nacional. Rev. cient. cienc. salud [online]. 2021, vol.3, n.1, pp.26-37. ISSN 2664-2891.  https://doi.org/10.53732/rccsalud/03.01.2021.26.

Introduction: the clinical forms of SARS CoV-2 range from asymptomatic, mild to severe symptoms with acute respiratory distress that can lead to death. Objective: to describe the clinical-epidemiological and laboratory characteristics and the predictors of mortality of adult patients with COVID-19 admitted to the National Hospital (Itauguá, Paraguay) between May and October 2020. Methodology: descriptive observational study of cross section of adult patients with COVID-19 admitted to the Hospital Nacional. The clinical and laboratory characteristics and the predictors of mortality were analyzed. Results: A total of 393 patients between 18 and 90 years of age (median: 56 years) were studied, the majority was male, from the Central Department. The main clinical manifestations were dyspnea, fever, and cough; 82.5% of the patients had some comorbidity, the most frequent was arterial hypertension (52.7%), followed by diabetes mellitus (30.8%) and obesity (24.4%). Among the laboratory findings, the most frequent were elevated levels of CRP (92.1%), ferritin (91%) and D-dimer (82%). 65.4% of the patients received heparin in an anticoagulant dose and 48.6% in a prophylactic dose. 93.4% received antibiotic coverage, 73.3% corticosteroids, 7.9% received convalescent plasma, and 3.8% remdesivir. Mortality was 30.3%, which was related (p≤ 0.05) with age ≥ 65 years, ICU admission, obesity, COPD, elevated values of D-dimer, LDH ferritin and procalcitonin. Conclusion: Mortality was high and was associated with prognostic factors reported previously.

Keywords : COVID-19; comorbidity; mortality, Paraguay.

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