Abstract

RODRIGUEZ, Leónidas; CARDOZO, Eva; MORILLA, Laura  and  PAVLICICH, Viviana. Effectiveness of nebulized furosemide in the treatment of severe asthma attack in children. Rev. cient. cienc. salud [online]. 2020, vol.2, n.2, pp.19-24. ISSN 2664-2891.  https://doi.org/10.53732/rccsalud/02.02.2020.19.

The hyperosmolarity of the secretions due to high ion concentrations has been correlated with bronchial hyperresponsiveness. This led to the consideration of the first uses of inhaled furosemide as an additional treatment for bronchial asthma. Objective: To assess whether the administration of nebulized furosemide as an adjunct medicine associated with conventional treatment of severe asthma in patients older than 5 years weighing ≥20 kg decreases the time of crisis and the stay in the Emergency Department (ED). Methodology: Randomized controlled study of patients with severe asthma exacerbation in a PED. Patients with comorbidity were excluded. The subjects were randomized into: Group 1 (Experimental) (n = 46): Furosemide associated with salbutamol and nebulized ipatropium and Group 2 (Control) (n = 36): Nebulization with Salbutamol and Ipratropium. Both groups received the usual pharmacological treatment. The first cut-off point was a decrease in the score by more than 2 points at 2 h after treatment; secondary points were decrease in score at 6 h, time spent in the emergency department and admission to the PICU. Results: The baseline characteristics were similar in both groups. The proportion of subjects with a decrease of more than two points in the score at 2 h of treatment in Group 1 was 76% compared to Group 2, which was 82% (p = 0.323). The mean stay was 19.2 ± 10.35 h in Group 1 vs 19.7 ± 14.5 h in Group (p = 0.670). No significant differences were found in the score and score of respiratory effort in measurements every 2 hours. Conclusion: Nebulized furosemide as an adjunct drug in the treatment of severe asthma did not significantly improve the clinical parameters or the stay in the PED.

Keywords : furosemide; salbutamol; ipratropium.

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