Introduction.

Tuberculosis (TB) continues to be a serious public health problem worldwide. In Paraguay, this infection has not been controlled. The HIV/AIDS epidemic has increased the burden of this disease. Objective. To determine the clinical-epidemiological characteristics of adult patients diagnosed with hospitalized TB at the Hospital Nacional de Itaugua between January 2008- March 2018. Methodology. Retrospective, descriptive cross-sectional study of consecutive cases in adult patients with the diagnosis of tuberculosis hospitalized at the Hospital Nacional de Itauguá from January 2008 to March 2018.Results. A total of 72 patients between 18 and 86 years (mean age: 41 ± 17.9 years) were included; 61.1% men, 59.7% from the Central Department, 15.8% unemployed, health professionals (4.2%). 87.5% had a comorbidity, HIV infection (55.5%), Systemic Lupus Erythematosus (6.3%), Type 2 Diabetes mellitus (6.3%), malnutrition (15.8%),ethylic (9.5%), smoking, corticosteroidconsumption(14.2%); prolonged fever (63.8%), acute fever (36.2%), pulmonary tuberculosis (50%), miliary (11.1%) and extrapulmonary tuberculosis: pleural (9.7%), meningeal (8.3 %), Central Nervous System(tuberculoma)9.7%,digestive(8.3%),lymphnode(6.9%),spine(2.7%),cutaneous(2.7%),urogenital (1,3%). Associated tuberculosis: miliary-cutaneous (10%), pulmonary-lymph node(10%),pulmonary-digestive (20%), pulmonary-pleural (10%), pulmonary-tuberculoma (40%).Tuberculosiswas revealing of HIV infection in 15.1%, mortality was 6.9%. There was an association between miliary tuberculosis and mortality. Conclusions. The majority of the patients were young adults, HIV infection was the main comorbidity. The pulmonary and extra pulmonary form was presented in equal proportion.