Abstract

NOGUEIRA, Juan Patricio. Effect of bariatric surgery on the metabolism of lipoproteins rich in triglycerides. Rev. cient. cienc. salud [online]. 2019, vol.1, n.1, pp.57-69. ISSN 2664-2891.  https://doi.org/10.53732/rccsalud/01.01.2019.57.

Insulin resistance and type 2 diabetes, driven largely by obesity, are characterized by an increase in triglyceride-rich lipoproteins (TRLs) due to both reduced TRL clearance from the circulation and increased production by the liver (apoB-100 containing VLDLs) and intestine (apoB-48 containing chylomicrons). Bariatric surgery is the only treatment currently that leads to marked, sustained weight loss. Here, we will review the effects of bariatric surgery on circulating triglyceride/TRL Bariatric surgery leads to a marked reduction in fasting and postprandial plasma triglyceride Available data suggest that bariatric surgery reduces triglyceride and intestinal and hepatic TRL production with increased clearance of hepatic TRL particles. Some bariatric surgery studies have reported no/weak correlation between weight loss and improvements in triglyceride/TRL, suggesting that as factors like GLP-1 beyond weight loss may contribute to the marked changes in TRL that occur postbariatric surgery.Further studies are also needed to compare the effects of various bariatric surgery procedures on TRL kinetics and to elucidate underlying mechanisms.

Keywords : obesity; bariatric surgery; insulin resistance; triglycerides; lipoproteins.

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