Abstract

ROJAS, Elías  and  CABRERA-VILLALBA, Sonia. Rheumatoid Arthritis and Pregnancy. Upgrade. Rev. parag. reumatol. [online]. 2020, vol.6, n.1, pp.36-47. ISSN 2413-4341.  https://doi.org/10.18004/rpr/2020.06.01.36-47.

Rheumatoid Arthritis (RA) is a frequent chronic inflammatory autoimmune condition, characterized by persistent inflammation of synovial joints. Managing RA during pregnancy is complex, considering the need for an appropriate balance between monitoring disease activity and mitigating symptoms with non-toxic but effective therapies. During pregnancy, a decrease in disease activity can be observed in 48 to 86% of patients. Some RA patients may develop flares, as well as pregnancy complications such as preterm labor, low birth weight and miscarriage. NSAIDs may increase the risk of subfertility in patients with RA. Hydroxychloroquine and sulfasalazine can be safely administered throughout pregnancy. Glucocorticoids at doses greater than 7.5mg/day prednisone or equivalent were associated with preterm delivery. During the first trimester of pregnancy, continuation of anti-TNF therapy is recommended. Both Leflunomide and Methotrexate should be discontinued when pregnancy is being planned.

Keywords : heumatoid Arthritis; pregnancy.

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