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Revista Virtual de la Sociedad Paraguaya de Medicina Interna
versión On-line ISSN 2312-3893
Resumen
GUEVARA TIRADO, Alberto. Alterations in the liver profile and other markers of asymptomatic patients who attend routine examinations in an urban area of Lima, Peru. Rev. virtual Soc. Parag. Med. Int. [online]. 2024, vol.11, n.1, e11122405. Epub 05-Feb-2024. ISSN 2312-3893. https://doi.org/10.18004/rvspmi/2312-3893/2024.e11122405.
Introduction:
The enzymes and markers of the liver profile allow us to evaluate the functionality and condition of the liver. Their elevations may be silent and have a certain prevalence in many adults.
Objective:
To determine the main alterations in the hepatogram in patients who attend routine medical consultation.
Methodology:
Descriptive, prospective and cross-sectional study carried out based on laboratory results from medical records of 364 female and male patients of all ages attending a polyclinic in the district of Villa El Salvador, Peru from January 2021 to July 2022. The variables were: age, sex, values of alanine aminotransferase (ALT), aspartate transaminase (AST), direct, indirect and total bilirubin, albumin, globulins and alkaline phosphatase (ALP).
Results:
In the total average of the sample, ALT was high (51.05 U/L), as well as total bilirubin (1.50 mg/dL) and ALP (135.84 U/L). ALT was high in men (54.92 U/L) and women (48.86 U/L) while AST was normal in women and high in men (48.24 U/L). Indirect bilirubin was high in men (1.33 mg/dL) and ALP was higher in both sexes (143.28 U/L in men and 126.38 in women). According to age group, AST values were highest in the age group equal to or greater than 40 years (49.99 U/L). ALT values were high in both sexes (55.96 U/L in men and 50.90 U/L in women), as well as total bilirubin, which was highest in the age group equal to or greater than 40 years (2.03 mg/dL). Indirect bilirubin, albumin and ALP were normal in the age group equal to or less than 39 years, but were elevated in the age group equal to or greater than 40 years (1.13 mg/dL, 5.77 gr/dL and 147.95 U/L, respectively).
Conclusions:
There are alterations in the liver profile of asymptomatic patients in the sample studied. Although they are not significantly large elevations, it is recommended to identify and treat the possible causes that could trigger these elevations, as well as carrying out more similar studies at a national level to characterize the liver profile of our population.
Palabras clave : liver function tests; alanine transaminase; aspartate aminotransferases; hyperbilirubinemia; liver disease.
