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Revista Virtual de la Sociedad Paraguaya de Medicina Interna
versão On-line ISSN 2312-3893
Resumo
GUEVARA TIRADO, Alberto. Correlation between basal glycemia and alanine aminotransferases in patients with and without diabetes from a polyclinic in Lima, Peru. Rev. virtual Soc. Parag. Med. Int. [online]. 2023, vol.10, n.2, pp.62-69. Epub 30-Set-2023. ISSN 2312-3893. https://doi.org/10.18004/rvspmi/2312-3893/2023.10.02.62.
Introduction:
Alanine aminotransferase is an important nexus in the metabolism of amino acids and carbohydrates, and is also a marker of liver inflammation. Previous studies showed the relationship between diabetes mellitus and this enzyme under different clinical contexts.
Objective:
To evaluate the correlation between basal glucose and alanine aminotransferase both in patients with and without type 2 diabetes mellitus.
Methodology:
Observational, analytical, and cross-sectional study conducted from January 2021 to June 2022 with a population of 566 patients divided into groups with type 2 diabetes mellitus (n 224) and without it (n 342). Patients aged 18 years or older with and without type 2 diabetes mellitus were included. Patients with multiple pathologies and/or diagnosed with diabetes less than 6 months were excluded. Inferential analysis was performed with Spearman's correlation test and the Kolmogorov-Smirnov normality test. The data was processed with the SPSS statistics 25™ software.
Results:
The correlation between glucose and alanine aminotransferase in subjects without diabetes was 0.212 (p=0.003) and the correlation between glucose and alanine aminotransferase in those with diabetes was -0.434 (p=0.015).
Conclusions:
Alanine aminotransferase is associated with greater intensity in patients with type 2 diabetes mellitus than in those without diabetes. The moderate and negative correlation in subjects with type 2 diabetes mellitus would indicate alterations in the interaction between alanine aminotransferase and glucose in which sustained hyperglycemia would play a relevant role, probably due to an increase in transamination activity.
Palavras-chave : blood glucose; alanine transaminase; nonparametric statistics; metabolism; data correlation..