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Revista Virtual de la Sociedad Paraguaya de Medicina Interna

On-line version ISSN 2312-3893


MARTINEZ, Lis Faviola Rondelli et al. Predictive factors of clinical evolution in hospitalized patients with lupus nephritis. Rev. virtual Soc. Parag. Med. Int. [online]. 2022, vol.9, n.2, pp.94-103. ISSN 2312-3893.



Lupus nephritis is a frequent complication in patients diagnosed with systemic lupus erythematosus, especially at an early age.


To determine predictive factors that intervene in the clinical evolution of hospitalized patients with lupus nephritis.


Observational, retrospective, cross-sectional study with an analytical component. Men and women, older than 18 years, with a diagnosis of lupus nephritis, who attended the Hospital Nacional of Itauguá, Paraguay, in the period 2018-2021, were included. Patients with incomplete medical records were excluded. The research was approved by the Ethics Committee of the National University of Itapúa.


Eighty-two patients with a recent or known diagnosis of lupus nephritis were studied, with a mean age of 31 ± 11 years (range 16-75 years), 68 patients were female and 46 of them had primary school. The average disease activity, measured by SLEDAI-2K, was 16±6 (range 4 - 32), and at the time of hospitalization 49 classified as severe activity. On admission, the mean creatinine value was 3.22±3.33 mg/mL, proteinuria 1820±2177 mg/day, C3 58±35 mg/dL and C4 11±9 mg/dL. Mortality occurred in 18 patients (22%). The most frequent causes of death were infections. The predictors of mortality were the evolution of the disease greater than 4 years and proteinuria in the nephrotic range (p <0.05).


The predictors of mortality in patients with lupus nephritis were proteinuria in the nephrotic range and disease time of less than 4 years of evolution.

Keywords : systemic lupus erythematosus; lupus nephritis; mortality.

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