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Revista Virtual de la Sociedad Paraguaya de Medicina Interna

On-line version ISSN 2312-3893


IBANEZ FRANCO, Elvis Javier  and  FRETES OVELAR, Alma María Carmelita. Posterior reversible encephalopathy syndrome in systemic lupus erythematosus. Rev. virtual Soc. Parag. Med. Int. [online]. 2022, vol.9, n.1, pp.140-146. ISSN 2312-3893.

Posterior reversible encephalopathy syndrome is a clinical and radiological entity characterized by neurological manifestations of insidious and progressive onset caused by alterations in cerebral vascular perfusion. We present two cases of patients with systemic lupus erythematosus (SLE) who developed posterior reversible encephalopathy syndrome due to refractory arterial hypertension.

Both cases came due to respiratory distress and generalized edema, with alterations in the renal profile and refractory arterial hypertension. The first is a known female patient with systemic lupus erythematosus in irregular treatment and chronic kidney disease in hemodialysis treatment who presented visual disturbances and seizures. The second is a female patient with SLE in irregular treatment and untreated lupus nephritis who also presented visual disturbances and seizures.

Neuroimaging studies in both patients show lesions at the occipital level compatible with posterior reversible encephalopathy syndrome. With the improvement in the blood pressure values, the neurological manifestations reverted in the second case but in the first case the seizures persisted.

Keywords : systemic lupus erythematosus; brain diseases; neurologic manifestations; hypertension.

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