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Revista Virtual de la Sociedad Paraguaya de Medicina Interna

On-line version ISSN 2312-3893


ESCOBAR-SALINAS, Jorge Sebastián  and  SOBARZO-VYSOKOLAN, Patricia María Beatriz. Neutrophil-lymphocyte index as a predictor of the development of severe pneumonia due to SARS-CoV-2 in the Hospital Nacional. Rev. virtual Soc. Parag. Med. Int. [online]. 2022, vol.9, n.1, pp.55-61. ISSN 2312-3893.


The neutrophil-lymphocyte index is the relationship between the absolute number of neutrophils and lymphocytes. Its increase predicts severe COVID-19 disease, even when inflammation is subclinical.


To determine the usefulness of the neutrophil lymphocyte index as a predictor of severity of SARS-CoV-2 pneumonia.

Materials and methods:

A case-control study was carried out, with a non-probabilistic sampling of consecutive cases from January to July 2021 in patients with SARS-CoV-2 infection from the Hospital Nacional, Paraguay. Patients with severe SARS-COV-2 pneumonia and controls were those with mild and moderate forms of pneumonia.


Three hundred ten patients (155 cases and 155 controls) were included. The age group ranged from 19 to 90 years (mean 53 ± 15 years). The neutrophil-lymphocyte index difference was 11.71 in cases vs 7.09 in controls (p 0.0001), with patients with an neutrophil-lymphocyte index greater than 3 being 5.08 times more likely to develop severe pneumonia.


neutrophil-lymphocyte index predicts the development of severe pneumonia to SARS-CoV-2.

Keywords : Coronavirus infections; neutrophils; lymphocytes; COVID-19; pneumonia; SARS-CoV-2.

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