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Revista Virtual de la Sociedad Paraguaya de Medicina Interna
On-line version ISSN 2312-3893
Abstract
ESCOBAR-SALINAS, Jorge Sebastián and SOBARZO-VYSOKOLAN, Patricia María Beatriz. Neutrophil-lymphocyte index as a predictor of the development of severe pneumonia due to SARS-CoV-2 in the Hospital Nacional. Rev. virtual Soc. Parag. Med. Int. [online]. 2022, vol.9, n.1, pp.55-61. ISSN 2312-3893. https://doi.org/10.18004/rvspmi/2312-3893/2022.09.01.55.
Introduction:
The neutrophil-lymphocyte index is the relationship between the absolute number of neutrophils and lymphocytes. Its increase predicts severe COVID-19 disease, even when inflammation is subclinical.
Objective:
To determine the usefulness of the neutrophil lymphocyte index as a predictor of severity of SARS-CoV-2 pneumonia.
Materials and methods:
A case-control study was carried out, with a non-probabilistic sampling of consecutive cases from January to July 2021 in patients with SARS-CoV-2 infection from the Hospital Nacional, Paraguay. Patients with severe SARS-COV-2 pneumonia and controls were those with mild and moderate forms of pneumonia.
Results:
Three hundred ten patients (155 cases and 155 controls) were included. The age group ranged from 19 to 90 years (mean 53 ± 15 years). The neutrophil-lymphocyte index difference was 11.71 in cases vs 7.09 in controls (p 0.0001), with patients with an neutrophil-lymphocyte index greater than 3 being 5.08 times more likely to develop severe pneumonia.
Conclusion:
neutrophil-lymphocyte index predicts the development of severe pneumonia to SARS-CoV-2.
Keywords : Coronavirus infections; neutrophils; lymphocytes; COVID-19; pneumonia; SARS-CoV-2.
