Introduction:

Sepsis represents a public health problem due to its high mortality and increasing incidence, with an increase of 9% estimated per year.

Objective:

To analyze the factors associated with mortality in sepsis and septic shock patients in the adult intensive care unit of the National Hospital of Itauguá from January 2019 to November 2020.

Subjects and Methods:

Observational, analytical study of cases and controls that included 57 patients (19 cases and 38 controls) diagnosed with sepsis and septic shock.

Results:

The following risk factors were found: Age over 60 years (OR = 3.98; p≤0.05), underlying pathology (OR = 18; p≤0.05), hospitalization greater than 20 days (OR = 5.52; p≤0.05), septic shock (OR = 6.42; p≤0.05), previous use of antibiotics (OR = 0.45; p≥0.05), delay in initiation of antibiotic therapy (OR = 2.80; p≥0.05), multiple organ failure (OR = 9.44; p≤0.05), elevated lactate (OR = 1.54; p≥0.05), elevated procalcitonin (OR = 4.42; p≤0.05), elevated CRP (OR = 5.58; p≥0.05) and mechanical ventilation (OR = 6.42; p≥0.05).

Conclusion:

Age over 60 years, being a carrier of an underlying pathology, hospitalization in intensive care for more than 20 days, entering septic shock, and admission with multiorgan failure were significantly associated with mortality.

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