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Revista Virtual de la Sociedad Paraguaya de Medicina Interna

On-line version ISSN 2312-3893


DOMINGUEZ GALLARDO, Laura Andrea  and  ORTEGA FILARTIGA, Edgar. Factors associated with lack of adherence to treatment in patients with type 2 diabetes mellitus. Rev. virtual Soc. Parag. Med. Int. [online]. 2019, vol.6, n.1, pp.63-74.  Epub Mar 01, 2019. ISSN 2312-3893.


Diabetes mellitus is a prevalent disease with a high cost for public health. However, the lack of therapeutic compliance prevents that the morbidity and mortality associated with this pathology can be avoided.


To determine the factors associated with the lack of adherence to treatment in patients with type 2 diabetes mellitus who attend the National Hospital of Itauguá in 2018.

Material and methods:

Observational, descriptive, prospective, longitudinal study, with analytical component, carried out in men and women older than 18 years with diagnosis of type 2 diabetes mellitus who attended the outpatient clinics of the National Hospital diabetes program in Itauguá in 2018. Adherence to treatment was determined with two validated scales that measured pharmacological (Morisky-Green) and non-pharmacological (IMEVID) adherence.


Three hundred and thirty eight patients were studied, 66% being female. The average age was 56 ± 7 years. The frequency of lack of adherence to treatment was 70% and the factors that were significantly associated were the presence of chronic complications (53%), pharmacological monotherapy (35%), presence of adverse drug effects (17%), time of evolution greater than ten years (16%) and poor doctor-patient relationship (16%).


There is a high frequency of lack of adherence to treatment in patients with diabetes mellitus (70%). The presence of chronic complications and pharmacological monotherapy were the most frequently associated factors. This information will allow decision-making to help patients improve their therapeutic compliance.

Keywords : therapeutic adherence; risk factors; diabetes mellitus.

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