Resumen

RUIZ ACOSTA, Alcides Gustavo; ACUNA DIAZ, Andrea Viviana; LABRANO ELIAS, Mónica María Eugenia  y  VALENZUELA VAZQUEZ, Christian Andrés. Pseudo Bartter syndrome associated with intravenous infusion of colistin. Rev. virtual Soc. Parag. Med. Int. [online]. 2018, vol.5, n.2, pp.79-84.  Epub 01-Sep-2018. ISSN 2312-3893.  https://doi.org/10.18004/rvspmi/2312-3893/2018.05(02)79-084.

Pseudo Bartter Syndrome (PB) is a rare pathology that consists of a salt-losing tubulopathy due to an alteration in the function of the ascending limp of the loop of Henle. It may be associated with the use of drugs such as colistin. It leads to a serum decrease of blood electrolytes with hyperreninism, hyperaldosteronism and metabolic alkalosis, with repercussion in the neuromotor and cardiovascular areas mainly. We present a series of 3 patients who received treatment with colistin, with a mean age of 66,6±20,4 years, predominantly female. PB Syndrome appeared at 13,6±4,7 days after the use of colistin. After the therapeutic initiation they presented serum decrease of calcium, potassium and magnesium, accompanied by metabolic alkalosis and normal blood pressure, all of them have shown resolution of the metabolic disturbances at 5,6±3,2 days. The appearance of PB Syndrome after the use of colistin is rare. The alterations produced by the tubulopathy do not respond to the insistent correction of the deficits only and require additional treatment for their resolution. The lack of knowledge of this complication could lead to fatal outcomes for patients and a timely intervention produces apparently encouraging solutions.

Palabras clave : Bartter syndrome - chemically induced; colistin - adverse effects; hypokalemia; hypocalcemia; alkalosis - metabolism.

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