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Revista Virtual de la Sociedad Paraguaya de Medicina Interna

On-line version ISSN 2312-3893

Abstract

MELGAREJO MARTINEZ, Laura Elizabeth et al. Use of second-line antibiotics for the treatment of uncomplicated acute cystitis in women: current approach. Rev. virtual Soc. Parag. Med. Int. [online]. 2018, vol.5, n.2, pp.62-72.  Epub Sep 01, 2018. ISSN 2312-3893.  https://doi.org/10.18004/rvspmi/2312-3893/2018.05(02)62-072.

Background and objective:

With this study we intended to identify the second-line antibiotics to be used in urinary tract infections (UTI), specifically in uncomplicated cystitis of women. Later, we proposed to present the prevalence of resistance to the second-line antibiotics of the germs most frequently found in the UTI in the Microbiology Laboratory of the Faculty of Medical Sciences of the National University of Asunción.

Material and method:

An observational, descriptive, cross-sectional study was carried out.

Results:

Escherichia coli has a resistance to cefuroxine lower than 20% on average, which was maintained in the observed period (2010-2017). The resistance to ampicillin-sulbactam of this germ is varying, from a high resistance in the first years of the observation to a progressive approach to 30% in the preceding years (on average 34%). Resistance to ciprofloxacin presents a rate higher than 25% in the studied years. Regarding the resistance of Klebsiella pneumoniae to the second-line antibiotics, a resistance greater than 30% was found for the group of cephalosporins, ampicillin sulbactam and ciprofloxacin in the last two years of observation.

Conclusions:

The data show an important resistance of Escherichia coli and Klebsiella pneumoniae isolated in urine cultures to the second-line antibiotics for the treatment of uncomplicated cystitis in women. Therefore, a great weight should be given to the results of the urine cultures for the proper use of these antibiotics.

Keywords : cystitis; Escherichia coli; Klebsiella pneumoniae; quinolones; microbial drug resistance; urinary tract infections; bacterial drug resistance.

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