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Revista Virtual de la Sociedad Paraguaya de Medicina Interna

On-line version ISSN 2312-3893


BENITEZ ARCE, Sandra Carolina  and  AVEIRO, Alba. Complications of long-term use of corticosteroids: Iatrogenic Cushing. Rev. virtual Soc. Parag. Med. Int. [online]. 2018, vol.5, n.2, pp.30-37.  Epub Sep 01, 2018. ISSN 2312-3893.


The iatrogenic Cushing syndrome is the result of inadequate, excessive and chronic use of glucocorticoids.


To describe the indications and complications of prolonged corticosteroid therapy, in addition to the clinical and demographic characteristics of the patients who attended the National Hospital in the 2010-2017 period.


Seventy patients were included, with an average age of 51±16 years (range 18-91 years), of which 40 (57%) were women and 30 (43%) were men. The mean BMI was 28.8 kg/m2.

The corticosteroids used were prednisone (86%) and dexamethasone (14%). Sixty percent was by self-medication and 40% by medical prescription. The indications for the use of corticosteroids were due to immunological diseases (62.86%) and non-immunological diseases (37.14%). The most frequent complication was obesity (97.14%). The mean value of glycated hemoglobin was 6.38±1.67 mg/dL (range 4.6-12.5 mg/dL).


The most used corticosteroid was prednisone. The predominant use reason was self-medication. The most frequent side effects were obesity, Cushingoid facies and dermatological alterations.

Keywords : corticosteroids; Cushing's syndrome; glucocorticoids; obesity.

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