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Revista Virtual de la Sociedad Paraguaya de Medicina Interna
On-line version ISSN 2312-3893
Abstract
TELLEZ BENITEZ, Jesús. Value of serum lactate as a prognostic factor for mortality in patients with sepsis. Rev. virtual Soc. Parag. Med. Int. [online]. 2017, vol.4, n.2, pp.11-18. ISSN 2312-3893. https://doi.org/10.18004/rvspmi/2312-3893/2017.04(02)11-018.
Introduction:
Serum lactate is one of the most important biomarkers of sepsis.
Objectives:
To determine the value of lactate and its association with mortality in patients with sepsis of any origin and to compare it secondarily with other scales.
Methodology:
A case (adult patients with sepsis and death) and control (adult patients with sepsis alive at discharge) design was applied in the Clinical Service, Adult Intensive Care Service and the Emergency Department of the National Hospital (Itauguá, Paraguay) from 2015 to 2016.
Results:
One hundred one patients, 34 dead (cases) and 67 alive (controls), were included. There were no statistically significant differences in sex and mean age between cases and controls. The most frequent infectious foci were pulmonary and abdominal. High lactate was found in 70% of the cases and in 30% of the controls (OR 4.5 CI95% 1.8-11) (p <0.001).
Conclusions:
There is an association between the serum lactate concentration at admission and hospital mortality in patients with sepsis, independently of comorbidity and age.
Keywords : sepsis; mortality; lactic acid; biomarkers; infection.
