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Revista Virtual de la Sociedad Paraguaya de Medicina Interna
On-line version ISSN 2312-3893
Abstract
SUAREZ VEGA, Dubraska Violeta; VELAZCO DE MALDONADO, Gladys Josefina and YEPEZ GUILLEN, Jenair del Valle. Histomorphometry of bone regeneration obtained with liposome-chitosan membrane system in an experimental model. Rev. virtual Soc. Parag. Med. Int. [online]. 2017, vol.4, n.1, pp.12-34. ISSN 2312-3893. https://doi.org/10.18004/rvspmi/2312-3893/2017.04(01)12-034.
Introduction:
We developed a chitosan scaffold in two physical forms, membrane and liposome as biomaterials for guided bone regeneration, which has not been studied histologically in an experimental model.
Objective:
To determine histologically the efficiency of chitosan in the guided bone regeneration in bone defects created in tibias of Wistar rats. This study was performed in 25 male adult Wistar rats with weight between 350 g - 500 g. A longitudinal defect was created in both tibias (control and experimental). The animals were randomly divided into 3 groups: 9 rats were evaluated at 3 weeks, 8 at 6 weeks and 8 at 9 weeks.
Results:
The histological findings confirmed that there was more osteoinductive activity and a higher level of bone maturity in the experimental tibias than in the control group.
Conclusions:
The chitosan liposome was efficient in the guided bone regeneration promoting more bone regeneration in less time in the experimental group than in the control group.
Keywords : guided bone regeneration (GBR); chitosan-based liposome; chitosan-membranes; Wistar rats.
