Abstract

LOPEZ, Nelson  and  REAL, Raúl. Response to hepatitis B vaccine in patients with chronic hemodialysis. Rev. virtual Soc. Parag. Med. Int. [online]. 2016, vol.3, n.1, pp.22-32. ISSN 2312-3893.  https://doi.org/10.18004/rvspmi/2312-3893/2016.03(01)22-032.

Introduction: Hepatitis B (HB) is still an important problem of Public Health due to the consequences in the infected patients. Among the groups with high risk of acquiring this virus, there are the patients with chronic renal disease (CRD) receiving hemodialysis treatment. Vaccination is an important prevention and protection method against the hepatitis B virus (HBV). Objectives:To determine the level of anti-HBsAg, find the prevalence of inadequate response to the HB vaccine and detect the risk factors associated with the lack of immunological response to HB vaccine. Methodology: This was a cross-sectional prospective descriptive observational study with analytical component. Adult patients with CRD receiving hemodialysis treatment three times a week in the National Hospital of Itauguá during 2015 were included. Anti-HBsAg was determined in all of them. Results: Eighty nine patients were included and 47% of them had inadequate response to HB vaccine with a slight predominance of men. Conclusions: The frequency of inadequate response to the vaccine was 47%. Age, smoking habits, co-morbidities and nutritional state by BMI were non-significant risk factors in the inadequate response to HB vaccine while years of hemodialysis and uremia were significantly related to this bad response.

Keywords : chronic renal disease; anti-HBsAg; hepatitis B vaccine; hemodialysis.

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