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Revista de salud publica del Paraguay

versión impresa ISSN 2224-6193versión On-line ISSN 2307-3349


ROMERO GOMEZ, Fabiola et al. Clinical practice guideline for the treatment and follow-up of people with differentiated thyroid cancer. Part I: Active surveillance. Rev. salud publica Parag. [online]. 2024, vol.14, n.1, pp.40-50. ISSN 2307-3349.


Thyroid cancer is a common disease in the world, with a higher prevalence of the differentiated type. Early diagnosis individualized and adaptive management can improve prognosis.


Generate evidence-based recommendations on the treatment and follow-up of adults with differentiated thyroid carcinoma (DTC).


Clinical practice guideline (CPG) based on systematic literature review (RSL) and consensus of clinical experts. The development group defined the range and four questions that were resolved through a review of evidence from existing CPGs, RSLs, primary studies published in Spanish or English in various sources of information since 2013. The research questions were: 1. What are the indications for active surveillance? How to carry it out? When and how often to carry it out? 2. What is the treatment and its indication in patients with thyroid nodules suspicious for cancer? 3. How and when to follow up patients with CDT according to dynamic risk? 4. What is the current management of iodine refractory patients? Evidence-based recommendations analyzed and discussed by the expert group in asynchronous sessions were proposed. The quality of the evidence was evaluated, and the recommendations were graded as strong or conditional and in favor or against based on the analysis of the quality of the evidence, implementation context (availability and implementation) and clinical expertise. In this document, is developed the first question, referring to active surveillance.


86 recommendations were proposed and agreed upon by the development group, categorized into treatment and follow-up to solve the questions raised. 10 of the recommendations correspond to active surveillance and are included in this document. Key recommendations include providing complete and timely information to patients, develop of multidisciplinary teams, individualized patient analysis for treatment decisions, routine dynamic risk staging to evaluate response to treatment and adjust it, minimization of futile procedures or that contribute little to the survival and quality of life of patients.


Recommendations are presented that longs to influence the standardization of the daily clinical practice of patients with DTC and better health outcomes.

Palabras clave : thyroid nodule; papillary thyroid carcinoma/ therapy; thyroid neoplasms/ surgical procedures; follow-up cares.

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