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Revista de salud publica del Paraguay

versão On-line ISSN 2307-3349

Resumo

OLMEDO, Gladys et al. Epidemiological and molecular characterization of Hepatitis C in the population that went to the Central Laboratory of Public Health, Paraguay 2013-2018. Rev. salud publica Parag. [online]. 2019, vol.9, n.1, pp.73-80. ISSN 2307-3349.  https://doi.org/10.18004/rspp.2019.junio.73-80.

Introduction:

Hepatitis caused by the hepatitis C virus (HCV) has become one of the main problems of emerging infectious diseases, responsible for 80% of chronic hepatitis with possible evolution to cirrhosis or hepatocellular carcinoma and causing a high cost for the health system.

Objective:

To describe the epidemiological profile and the genotypes of HCV in patients who attended the Central Public Health Laboratory (LCSP).

Materials and methods:

Descriptive study; included 162 patients with Hepatitis C infection referred to the LCSP between 2013 and 2018, for follow-up and / or genotyping. Genome amplification was performed using the polymerase chain reaction technique in real time prior to reverse transcription (RT-PCR). To a subsample with detectable PCR and viral load> 500 IU / ml, the genotype was determined (n = 52).

Results:

The mean age was 44.2 ± 15.6 years, 52.5% were men. The 8.02% had high viral load, 32.09% low and 59.87% undetectable. The genotype distribution was as follows: 61.5% genotype 1 (28.1% 1a, 53.1% 1b and 18.8% genotype 1 without subtyping), 15.4% genotype 2, 15.4% genotype 3 and 7.7% genotype 4.

Conclusions:

The present work shows the importance of the implementation of molecular techniques applied to the epidemiological surveillance of our country in order to establish programs of early detection and adequate monitoring of patients, since genotypic characterization helps to determine the most appropriate therapeutic strategies and predict the antiviral response. It is confirmed that genotype 1 is the one that circulates more frequently, with a high predominance of subtype 1b.

Palavras-chave : Molecular Biology; Hepatitis C; Genotype; Molecular Epidemiology; Paraguay.

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