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Revista de salud publica del Paraguay

Print version ISSN 2224-6193On-line version ISSN 2307-3349


MORINIGO M, Macarena; BURGOS, Rodrigo; CAMPUZANO-BUBLITZ, Miguel Ángel  and  KENNEDY, María Luisa. Evaluation of the effect of Aloe barbadensis on weight in normal and obese mice. Rev. salud publica Parag. [online]. 2018, vol.8, n.1, pp.21-26. ISSN 2307-3349.

Obesity is the most frequent metabolic disorder, for the treatment is fundamental to change the type of food and maintain a healthy lifestyle. Misleading advertising of so-called miraculous products leads to excessive, uncontrolled consumption and without prior evaluation of the effect on weight or their possible toxicity. A preliminary investigation was designed in mice, to verify the effect of the juice of Aloe barbadensis and a commercial product on the weight of normal and obese mice induced by monosodium glutamate(MSG),after four weeks of treatment. The group of mice induced to obesity with MSGhad a weight change percentage of 160.5 ± 37.5%, while in the group with normal body weight was of 59.4 ± 12.1%, this difference was significant (p<0,001). In the obese mice that received the juice of A. barbadensis, a non-significant weight decrease of 2.8% was achieved when compared with the weight at the beginning of the intervention (p(0.05). In obese mice treated with the commercial product,an increase in weight was observed, although in a smaller proportion than the obese ones that received water (3.5% and 4.4%, respectively). The results indicated that Aloe barbadensis juice induced a greater weight loss in obese animals, compared to the commercial product, however, this is not significant in the period considered.

Keywords : Aloe barbadensis; body weight; obesity; monosodic glutamate; mice.

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