Abstract

FERREIRA B., Francisco P. et al. Chemical and biological study of ethanolic raw extract of leaves from Schinus weinmannifolia Mart ex Engl (Molle’i) in the location of Pirareta (Cordillera, Paraguay). Rep. cient. FACEN [online]. 2023, vol.14, n.1, pp.11-24. ISSN 2222-145X.  https://doi.org/10.18004/rcfacen.2023.14.1.11.

The Schinus weinmanniifolia (Molle'i) is a plants used in infusion of leaves to treat tonsillitis, sore throats, cough and inflammation of gum. We try to establish a relationship between the secondary metabolites present and their biological activities, the qualitative Phytochemical Screening of the crude extract, Total Phenolic compounds, Total Flavonoids as well as Antioxidant Activity, Hemolytic Activity and LD50 in Drosophila melanogaster was determined. The results revealed the presence of hydrolysable Tannins, saponins and sterols. In the bioassays, high Antioxidant Activity (IC = 39.9%), and an antimicrobial activity of the ethanolic crude extract were observed against strains of E. coli, S. typhimurium, E. faecalis, P. aeruginosa, C. albicans. An LD50 of 15.3 mg.mL-1 was established in Drosophyla melanogaster and also a hemolytic activity of IC of 179 μg.mL-1 with an activity of 55.9%. These values represented a first contribution in order to determine scientifically their biological activity and correlate with the content of molecules.

Keywords : Phytochemical screening; Phenolic Compounds; Flavonoids; Antioxidant; Antimicrobial; Hemolytic Activity.

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