Abstract

GOMEZ, Fredy J. et al. Biological dosimetry with the Comet and Micronucleus tests in patients with serious hyperthyroidism, toxic adenoma and Plummer disease treated with I¹³¹. Rep. cient. FACEN [online]. 2021, vol.12, n.2, pp.88-95. ISSN 2222-145X.  https://doi.org/10.18004/rcfacen.2021.12.2.88.

Radioactive Iodine 131 (I131) therapy is a Nuclear Medicine procedure used to treat patients with dif- fuse or nodular hyperthyroidism and in differentiated thyroid cancer (DTC) in metastatic stages. Diffuse Graves' hyperthyroidism and its nodular varieties require differentiated doses. In the present work, we sought to determine the absorbed doses of I131 involved in the treatment of hyperthyroidism, using physical dosimetry methods with the MIRD formalism that protocolizes the conjugate image dosimetry in Nuclear Medicine, compared with the comet and micronucleus test, with which We established the feasibility and sensitivity of the tests to the radiation doses involved. It has been possible to determine that the percentage of DNA in the comet's tail turns out to be a good indicator of the I131 absorption capacity in the thyroid gland, which as the concentration in blood decreases, greater repair of the damage could be demonstrated and can be used As a reference in new epidemiological studies as an indicator of treatment progression, the DNA repair capacity has also been demonstrated, allowing such extreme radiation doses to have a therapeutic action and can be distributed within a period of 50 to 100 days within the body. , allowing to observe the level of damage in the DNA molecule through the comet test.

Keywords : Hyperthyroidism; Dosimetry; Iodotherapy; Comet Test.

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