Abstract

LOPEZ, Fátima; BLANES, Monserrat; RIOS, María  and  VERA, Lidia. Pre and post hemodialysis determination of Urea, Creatinine and Electrolytes in renal patients at the National Hospital, Itaugua. . Rev. Nac. (Itauguá) [online]. 2012, vol.4, n.1, pp.34-40. ISSN 2072-8174.

ABSTRACT Introduction: Chronic renal disease is the irreversible and progressive reduction of glomerular filtration rate (GFR) of the kidney, leading to a progressive retention of toxic substances. It is a public health problem. Its most serious manifestation is chronic renal failure, subsidiary of replacement therapy through dialysis or kidney transplant. The efficiency of hemodialysis can be measured by urea reduction ratio (URR) which must be > 65% and urea clearance (Kt / V) that should be > 1.2. Objectives: To describe the underlying conditions that lead the study population to hemodialysis. Determine the pre and post hemodialysis values of urea, creatinine and electrolytes. To estimate the efficiency of hemodialysis based on the values of URR and Kt / V. Materials and Methods: Observational, descriptive, retrospective cross-sectional with analytical components, conducted in 100 patients with chronic renal disease, undergoing hemodialysis at the National Hospital, Itauguá from June to August 2011. Results: Of the 100 patients studied, the mean age was 41 ± 14 years. There was a male gender predominance (62%). Patients were mainly originally from the Central Department (55%). The underlying diseases were: diabetic nephropathy 19%, nephroangiosclerosis 18% and renal polycystosis 13%. 24% had no labeled initial nephropathy. An average 36.4% urea and 42.2% creatinine decrease was observed. As for electrolytes, there was no significant pre or post hemodialysis difference.300 pre and post hemodialysis urea, creatinine and electrolytes determinations were performed during the months of study. Regarding URR, a 53% reduction was observed in the determinations of the total population in the months of study. Making a comparison of the URR in both genders, there was a 83% reduction in women and a 34% reduction in men. As for the results of kt / V, an average value of 1.4 was obtained in the study period. Comparing both genders a higher kt / V was observed in women 1.5 versus 1.2 in men, not having studied the causes of such difference. Conclusions: The most common cause of chronic renal disease was diabetic nephropathy. Using the URR and Kt / V variables, hemodialysis has a higher efficiency in women than in men.

Keywords : Chronic renal disease; hemodialysis; urea reduction ratio; urea clearance.

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