Abstract

BORDENAVE, Laura; TORRES DE TABOADA, Estela  and  MONTIEL-JAROLIN, Dora. Systemic lupus erythematosus in men: clinical and immunologic features. . Rev. Nac. (Itauguá) [online]. 2012, vol.4, n.1, pp.21-26. ISSN 2072-8174.

ABSTRACT Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease that affects women nine times more than men. The marked influence of gender on the occurrence of SLE confirmed the importance of genetic and hormonal factors in the disease. SLE in males is characterized by a higher frequency of serositis, severe renal injury and poor outcome. Objetive: To determine the clinical and immunological features of male patients with SLE. Material an Methods: an observational, descriptive, transverse cutting, we studied 45 male patients with SLE over 18 in the National Hospital Itauguá from January 2005 to December 2010. Results: Of a total of 200 patients with SLE, 155 were women (77.5%), males 45 (22.5%), mean age was 41 years. The time interval between onset of symptoms and diagnosis was 15 months. Clinical features: 80% arthralgia, pericarditis 60%, 54% hair loss, pleuritis 42%, weakness 42%, 40% prolonged fever, arthritis 38%, photosensitivity 37%, myalgia 33%, 31% acute fever. Laboratory: anemia 93%, 65% lymphopenia, leukopenia 41%, thrombocytopenia 4%, ANA positive in 91%, anti-DNA positive 68%, decreased by 68% C3, C4 decreased by 71%. Proteinuria greater than 1000 mg. 35% between 500-1000 mg. 20%, less than 500 mg. 45%, hematuria 46%. Renal biopsy was performed in 22 (49%) patients, being glomerulonephritis type IV (63%), type II (27%) and type III (9%). Conclusion: The clinical features were more representative articular manifestations, followed by serositis (pericarditis and pleuritis) and renal (gradeIV). As for the immunological markers showed a high percentage of positive antinuclear antibodies plus hypocomplementemia.

Keywords : Systemic Lupus Erythematosus / Men; joint manifestations; serositis; pericarditis; immunological markers; Paraguay.

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