Abstract

CORONEL, Claudia et al. Adverse effects secondary to Amphotericin B Liposomal. Rev. Inst. Med. Trop. [online]. 2024, vol.19, n.1, pp.39-43. ISSN 1996-3696.  https://doi.org/10.18004/imt/2024.19.1.39.

Liposomal amphotericin B has been used to replace amphotericin B deoxycholate to reduce its associated adverse effects, especially nephrotoxicity. We present the case of a 47-year-old male patient without known previous heart disease with a diagnosis of visceral leishmaniasis, who presented myocarditis, rhabdomyolysis and peripheral polyneuropathy after starting treatment with liposomal amphotericin B. This case highlights the importance of other adverse effects to consider, such as cardiotoxicity, related to the administration of liposomal amphotericin B and other effects not previously reported such as peripheral polyneuropathy.

Keywords : Amphotericin B; cardiomyopathy; peripheral polyneuropathy; rhabdomyolysis.

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