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Revista del Instituto de Medicina Tropical

Print version ISSN 1996-3696

Abstract

LAMBARE, Juan Manuel et al. Pulmonary Coinfection by Rhodococcus equi and Histoplasmosis in a patient with AIDS. Rev. Inst. Med. Trop. [online]. 2016, vol.11, n.2, pp.33-35. ISSN 1996-3696.  https://doi.org/10.18004/imt/201611233-35.

Introduction

Rhodococcus equi, an intracellular pathogen, affects immunecompromised patients, where lung infection is the most frequent form of presentation. Histoplasmosis, deep mycosis, usually disseminated in patients with AIDS, is related to low CD4.

Clinical Case Male, 43 years, HIV +, with WB: 08/04/15, CD4: 13, CV: 92.076, ART with Tenofovir + Lamivudine + Efavirenz, 5-day fever, cough with yellowish expectoration and type pain Stitch in left hemithorax. MV physical examination decreased in left hemithorax, crackling in midfield. Mild hepatosplenomegaly. Painless violaceous papular lesions in the thorax and right upper limb. Hemoculture: Rhodococcus equi. Chest CT: hyperdense image with cavitations in the middle field of the left lung parenchyma. Skin biopsy, pathological anatomy: SK at macula stage. Fibrobronchoscopy + transbronchial Bx: BAL (-), pathological anatomy: severe granulomatous inflammatory process. Pancytopenia during hospitalization. PAMO (-). BxMO: microgranuloma of aetiology to be determined. Culture of MO: Histoplasma capsulatum. Received treatment with Levofloxacin 750mg / d + Azithromycin 500mg / d + Rifampicin 900mg / d and amphotericin B deoxycholate with good clinical evolution.

Discussion

The persistence of febrile spikes forced invasive procedures to diagnose occult coinfection. It is well known the condition of immunosuppressed by these pathogens.

Keywords : immunodepressed patients; microgranuloma; Hepatosplenomegaly.

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