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Revista del Instituto de Medicina Tropical

Print version ISSN 1996-3696


ARAYA, Soraya et al. Increasing severity of Dengue in children in successive epidemics in Paraguay. Rev. Inst. Med. Trop. [online]. 2015, vol.10, n.2, pp.04-12. ISSN 1996-3696.

Abstract Introduction: The clinical expression of infection with dengue virus (DENV) varies from mild to severe, the prevalence vary epidemic. Objective: To characterize the clinical behavior of dengue in children hospitalized in a referral center of Paraguay, during outbreaks (2007, 2009-10 and 2011). Materials and Methods: A descriptive, retrospective study based on a review of medical records of patients (pts) hospitalized at the Institute of Tropical Medicine (IMT) with discharge diagnosis of dengue confirmed (2007-2009) and prospective (2011) by lab (IgM Elisa, NS1, RT-PCR) or epidemiological link. They were analyzed and compared demographic, clinical, laboratory data and complications. Results: 270 children were hospitalized with a diagnosis of dengue, corresponding 98 pts (36%) of the 2007 outbreak, 49 pts (18%) the outbreak of 2009-10 and 123 pts (46%) outbreak of 2011. The predominant serotypes by period were DENV-3, DENV-1 and DENV-2 respectively. There was no significant difference in age of patients per period (13 ± 3 years, 12.5 ± 3.6 years and 11 ± 3 years, respectively). The incidence of visceral complications (encephalitis / myocarditis / hepatitis) were higher in 2011 outbreaks (54/123, 44%) and 2,007 (24/98, 24%) compared to 2009-10 (5 / 49,10%) (p <0.01), and the frequency of severe bleeding [18/123 pts (14.6%) in 2011 vs. 1/49 (2%) in 2009/10, p <0.05] and thrombocytopenia < 50000 (29% in 2011 vs. 12% in 2009/10, p <0.05). Mortality was low in all three periods (1%, 2% and 1.6%). Conclusions: This series reveals the particular characteristics of each sprout in relation to the severity. During the circulation of DENV-3 and DENV-2 more frequently more severe cases including visceral involvement it was observed.

Keywords : Dengue; dengue grave; niños; dengue; severe dengue; children.

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