Abstract

CUEVAS, Mirna; TABOADA, Aurelia  and  BENITEZ, Gustavo. Associated Ergotism Protease Inhibitor in immunesuppressed HIV Patient. Rev. Inst. Med. Trop. [online]. 2014, vol.9, n.2, pp.29-32. ISSN 1996-3696.

Abstract Introduction: Ergotism is a complication of chronic intake or acute ergot derivatives. They are metabolized in the liver CYP3A4 and lnhibidores Protease (IP) (as Ritonavir) and many other drugs. The IP act as competitive inhibitors of CYP3A4 and ergot concentrations rise to toxic levels, even at low doses thereof. This case clearly shows the effects of drug interaction between Ergotamine and protease inhibitors in patients with AIDS. Objective: To demonstrate the importance of drug interactions with antiretroviral drugs.

Keywords : AIDS; Clinical infection; Ritonavir.

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