Revista del Instituto de Medicina Tropical
versão impressa ISSN 1996-3696
SANABRIA, Gabriela et al. Correlation of serotypes, antimicrobial sensitivity and resistance in children with invasive infections by Streptococcus pneumoniae in a reference center of Asuncion-Paraguay. Review 6 years. Rev. Inst. Med. Trop. [online]. 2009, vol.4, n.2, pp.14-24. ISSN 1996-3696.
Streptococcus pneumoniae is the main agent in extra-hospital pneumonia, meningitis in adults and acute otitis media in children. Aim: To determine the susceptibility, antibiotic resistance and serotypes of strains of S. pneumoniae isolated from patients admitted to the pediatric ward of the Institute of Tropical Medicine and correlate with the severe clinical picture presented. Results: We evaluated a total of 95 strains over a period of six years. 98% corresponded to samples from invasive infections. Of the 78 isolates, susceptibility testing was performed in 73 of them (94%) of which 37% (27/73) had decreased susceptibility to penicillin by Kirbi-Bauer method, 10% of the strains were resistant to erythromycin, tetracycline 12%, 59% to cotrimoxazole (trimethoprim-sulfamethoxazole) and 3% to chloramphenicol. We performed the minimum inhibitory concentration (MIC) to 69 strains (88%) where it was found highly resistant to penicillin in 13% (9 / 69), intermediate resistance in 6% (4/69) and cefotaxime resistance in 3 % of isolates. All strains tested were sensitive to vancomycin. It found 13 different serotypes. The 14, 5, 1 were common in all diseases studied. Conclusion: The strains of S. pneumoniae that have a higher percentage of resistance to penicillin belong to serotype 14 as well as strains with multidrug resistance. We isolated a single strain 23F to penicillin MIC 0.015 to 0.03 and cefotaxime
Palavras-chave : multirresistance; serotypes; Streptococcus pneumoniae.