Abstract

ARELLANO, Nelson Darío  and  PAEZ, Larissa Inés. Breast cancer metastasis as a cholangiocarcinoma or Klatskin-like lesion. An. Fac. Cienc. Méd. (Asunción) [online]. 2021, vol.54, n.2, pp.145-150. ISSN 1816-8949.  https://doi.org/10.18004/anales/2021.054.02.145.

A 60-year-old female, with a medical history of a ductal carcinoma of the left breast, presented with sharp pain in epigastrium with 6 months of dyspepsia, early satiety and pyrosis and with the loss of 9 kilograms in 2 months. She referred choluria and denied jaundice and acholia. Liver function tests showed a cholestasis pattern with only elevated Gama Glutamyl Teransferase and alkaline phosphatase. She was diagnosed with a hilar cholangiocarcinoma based on abdominal CT and MRI findings, with a parenchymal nodule in segment 8 of the liver as a periductal infiltrating tumor. The presumed diagnosis was Klatskin Tumor, but the biopsied site was compatible with breast ductal carcinoma metastasis (CK7 + / GATA3 +). The complementary report showed negative HER-2 and negative estrogen (ER) and progesterone (PR) so the final immunophenotype is ER- / PR-; HER2- with proliferation index Ki67 <5%, a triple-negative breast cancer metastasis.

Keywords : Klatskin; breast; cholangiocarcinoma..

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