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Anales de la Facultad de Ciencias Médicas (Asunción)
Print version ISSN 1816-8949
Abstract
VILLALBA E, Mario R and RUOTI C., Miguel. Utility of insulin-like growth factor-binding protein type 1 in premature membrane rupture. An. Fac. Cienc. Méd. (Asunción) [online]. 2018, vol.51, n.1, pp.57-64. ISSN 1816-8949. https://doi.org/10.18004/anales/2018.051(01)57-064.
Introduction:
We do not have clear evidence of the loss of amniotic fluid observed by speculum examination, so the diagnosis of premature rupture of membranes can often be uncertain and appropriate and complementary diagnostic tests are needed for decision making. Objective: to know the diagnostic accuracy of insulin-like growth factor-binding protein-1 (IGFBP-1) in the premature rupture of membranes when compared with the measurement of the greater pocket by ultrasound and the Ferning test.
Material and methods:
102 pregnant women from 24 to 37 weeks with signs and / or symptoms of rupture of membranes were eligible, which were evaluated with the IGFBP-1, ultrasound and Ferning Test.
Results:
For IGFBP-1 95% sensitivity (S), 95% specificity (E), 95% positive predictive value (PPV) and 96% negative predictive value (NPV) were obtained. For the Ferning Test values of 85%, 25%, 25% and 83% respectively were obtained. While for ultrasound the findings were 81%, 29%, 56% and 58% respectively.
Conclusion:
the IGFBP-1 assay was the most accurate method to diagnose the premature rupture of membranes with the highest sensitivity, specificity, positive predictive value and negative predictive value.
Keywords : insulin-like growth factor binding protein-1; Ferning test; echography mediations; pregnancy; premature rupture of membranes.