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Anales de la Facultad de Ciencias Médicas (Asunción)

Print version ISSN 1816-8949


BRITEZ, M  and  UNIVERSIDAD NACIONAL DE ASUNCION.. Departamento de Nefrología. Hospital de Clínicas. Facultad de Ciencias Médicas et al. Calciphylaxis in a patient on hemodialysis. Anatomopathological Clinical Study. An. Fac. Cienc. Méd. (Asunción) [online]. 2012, vol.45, n.1, pp.59-64. ISSN 1816-8949.

ABSTRACT Arterial calcification was described by Bryant and While in 1898 in patients with chronic renal failure. In 1962 Selye called it calciphylaxis. 1 to 4% of patients on hemodialysis suffer from it. Calciphylaxis or calcific uremic arteriopathy is an entity with poor prognosis and high mortality, of nearly 80 percent. It is a rare and severe disorder characterized by calcification of the medial layer of small arterioles leading to ischemia and necrosis. The term calciphylaxis implies a systemic and anaphylactic reaction that was first observed in animal models. Calcific uremic arteriolopathy was proposed to describe the phenomenon in chronic renal failure, but the term Calciphylaxis is still used. Vascular calcification of the arterioles compromises skin, subcutaneous tissue and even muscles that ulcerate and get over infected and if not healing can lead to septicemia and the death of the patient. The diagnosis is anatomopathological. We report a case of a 47 years old woman, with diabetes type 2, with two years on hemodialysis, with dermal nodule in hypogastrium and mammary region, indurated, painful, necrotic, ulcerated whose pathology confirmed Calciphylaxis. It discusses the most important aspects of this pathology, with emphasis on diagnosis and risk factors for prevention. Keywords: Calciphylaxis, hemodialysis, uremia.

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